纳米材料在结核病治疗中的研究进展  

Research progress of nanomaterials in the treatment of tuberculosis

作　　者：杨廷玉 萨日娜 王芙蓉 陈琛 郑兰兵 Yang Tingyu;Sarina;Wang Furong;Chen Chen;Zheng Lanbing(Department of Scientific Research,Inner Mongolia Fourth Hospital(Chest Hospital),Hohhot 010000,China;Department of Infectious Diseases,Inner Mongolia Fourth Hospital(Chest Hospital),Hohhot 010000,China)

机构地区：[1]内蒙古自治区第四医院(胸科医院)科研部,呼和浩特010000 [2]内蒙古自治区第四医院(胸科医院)传染病科,呼和浩特010000

出　　处：《中国防痨杂志》2025年第5期660-665,共6页Chinese Journal of Antituberculosis

基　　金：首府地区公立医院2023年高水平临床专科建设科技项目(2023SGGZ147);内蒙古自然科学基金(2023LHMS08035)。

摘　　要：目前,结核病治疗仍面临着严重的挑战。传统药物治疗带来了多种问题,如治疗时间长、患者依从性差、生物利用度低等。特别是耐药菌的产生,严重影响了治疗效果。但纳米材料的出现却可以克服当前结核病治疗中的问题,改变治疗方式,从而提高治疗效果。基于此,作者对纳米材料在结核病治疗中的最新研究进展进行了综述,对纳米材料在治疗过程中发挥的功能进行了分类和讨论;简述了直接治疗纳米材料,重点介绍了药物递送纳米材料,并对最新的光疗纳米材料进行了探讨。最后,对纳米材料所面临的挑战以及未来的发展进行了总结和展望。At present,tuberculosis(TB)treatment still faces serious challenges.Traditional drug therapy has brought various issues,such as long treatment time,poor patient compliance,and low bioavailability.Especially,the emergence of drug-resistance seriously affects the effectiveness of treatment.However,the emergence of nanomaterials can overcome current problems in the treatment of TB,change treatment approaches,and thus improve treatment effect.Based on this,this article reviews the latest research progress of nanomaterials in the treatment of TB,classifies and discusses the functions of nanomaterials in the treatment process,briefly describes the nanomaterials used for direct treatment,focuses on nanomaterials used for drug delivery,and discusses the latest phototherapy nanomaterials.Finally,a summary and outlook are provided on the challenges faced by nanomaterials and their future development.

关 键 词：结核 纳米粒子 抗菌剂 药物载体 光疗 

分 类 号：R52[医药卫生—内科学] TB383[医药卫生—临床医学]