机构地区:[1]Department of Internal Medicine,Dow Medical College,Karachi 74200,Sindh,Pakistan [2]Department of Cardiology,Duke University Hospital,Durham,NC 27710,United States [3]Department of Internal Medicine,Jersey Shore University Medical Center,Neptune,NJ 07753,United States [4]Department of Internal Medicine,Dow Medical College,Dow University of Health Sciences,Karachi 74900,Sindh,Pakistan [5]Department of Medicine,Shaheed Mohtarma Benazir Bhutto Medical College Liyari,Karachi 74900,Pakistan [6]Department of Internal Medicine,Services Institute of Medical Sciences,Lahore 54000,Punjab,Pakistan [7]Department of Internal Medicine,Rawalpindi Medical University,Rawalpindi 74200,Pakistan [8]Department of Internal Medicine,Batterjee Medial College,Jeddah 21442,Saudi Arabia [9]Department of Internal Medicine,SSM Health St Louis University,St Louis,MO 63104,United States [10]Department of Internal Medicine,Liaquat Institute of Medical and Health Sciences,Thatta 73130,Sindh,Pakistan [11]Department of Biophysics,Medical University of Silesia in Katowice,Katowice 40-055,Poland [12]Department of Internal Medicine,New York Institute of Technology,College of Osteopathic Medicine,Westbury,NY 11568,United States
出 处:《World Journal of Nephrology》2025年第2期95-104,共10页世界肾病学杂志(英文)
摘 要:BACKGROUND Renal complications of diabetes mellitus pose a significant public health challenge,contributing to substantial morbidity and mortality globally.Understanding temporal trends and regional disparities in mortality related to diabetic nephropathy is crucial for guiding targeted interventions and policy decisions.AIM To display the trends and disparities of diabetic nephropathy related mortality.METHODS A retrospective analysis was conducted using death certificate data from the center for disease control and prevention(CDC)wide-ranging online data for epidemiologic research analysis(WONDER)database,spanning from 1999 to 2020,to investigate mortality related to renal complications of diabetes in adults aged 35 or above.Age-adjusted mortality rate(AAMR)per 100000 persons and annual percent change(APC)were computed,with stratification by year,sex,race/ethnicity,and geographic region.RESULTS Between 1999 and 2020,a total of 525804 deaths occurred among adults aged 35 to 85+years due to renal-related issues associated with diabetes.AAMR for renal-related deaths in adult diabetic patients showed a consistent increase from 1.6 in 1999 to 34.9 in 2020(average APC[AAPC]:17.23;95%confidence interval[CI]:13.35-28.79).Throughout the study period,men consistently had higher AAMR(overall AAMR for men:17.8;95%CI:17.7-17.9).In 1999,the AAMR for men was 1.8,increasing to 44.2 by 2020(AAPC:17.54;95%CI:13.09-29.53),while for women,it was 1.6 in 1999 and rose to 27.6 by 2020(AAPC:15.55;95%CI:13.35-21.10).American Indian/Alaska Native adults exhibited the highest overall AAMR(36.1;95%CI:35.2-36.9),followed by Black/African American(25.5;95%CI:25.3-25.7).The highest mortality was observed in the Western(AAMR:16.6;95%CI:16.5-16.7),followed by the Midwestern region(AAMR:14.4;95%CI:14.314.4).Significant variations in AAMR were observed among different states,with Oklahoma recording the highest(21.2)and Connecticut the lowest(7).The CDC WONDER database could potentially have omissions or inaccuracies.It does not provide data outs
关 键 词:Kidney diseases Mortality Chronic disease COMORBIDITY Diabetes mellitus
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