Plantamajoside:A potentially novel botanical agent for diabetes mellitus management  

作　　者：Na Liu Wei-Tao Yan Kun Xiong 

机构地区：[1]Department of Anatomy and Neurobiology,School of Basic Medical Science,Central South University,Changsha 410013,Hunan Province,China

出　　处：《World Journal of Diabetes》2025年第5期8-15,共8页世界糖尿病杂志(英文)

基　　金：Supported by the National Natural Science Foundation of China,No.82303047,No.82372507,No.82172196 and No.32401046;Natural Science Foundation of Hunan Province,No.2022JJ40801.

摘　　要：Diabetes mellitus(DM)and its associated complications are metabolic disorders characterized by hyperglycemia,leading to high morbidity and reduced quality of life worldwide.This global healthcare problem imposes substantial personal and social burdens that warrant comprehensive and in-depth investigation.Plantamajoside(PMS),a naturally bioactive ingredient derived from the traditional Chinese medicinal herb Plantaginis Herba,exhibits a range of pharmacological properties,including anti-inflammatory,antioxidative,and antitumor effects,and has been traditionally utilized in clinical applications such as removing phlegm and clearing heat.However,the potential biological impact of PMS on DM remains largely unexplored.Recent research by Wang et al reported the therapeutic potential of PMS in type 2 DM(T2DM)and elucidated the underlying molecular mechanisms.Specifically,PMS mitigates endoplasmic reticulum stress and apoptosis of pancreaticβ-cells by upregulating DnaJ heat shock protein family(Hsp40)member C1,thereby alleviating pancreaticβ-cell damage and ameliorating T2DM progression.Given the novel and protective effect of PMS on pancreaticβ-cells,this natural ingredient emerges as an innovative and promising therapeutic strategy for improving DM outcomes.PMS has been shown to modulate key signaling pathways involved in multiple types of regulated cell death(RCD),such as apoptosis and autophagy.Various forms of RCD,including apoptosis,ferroptosis,pyroptosis,autophagy,and PANoptosis,contribute to the pathogenesis of DM and its associated complications.There is significant potential for PMS to exert protective effects onβ-cells against these forms of RCD and to provide a multitarget approach to DM therapy.Therefore,further exploration into whether PMS shields pancreaticβ-cells from these types of RCD,coupled with elucidating the underlying molecular mechanisms,will facilitate the development of more effective therapeutic strategies for DM.Additionally,further investigation on PMS in conjunction with other therapeu

关 键 词：Diabetes mellitus Pancreaticβ-cells Regulated cell death Traditional Chinese medicine Plantamajoside 

分 类 号：R285[医药卫生—中药学]