Systemic immune indicators for predicting renal damage in newly diagnosed type 1 diabetic children  

作　　者：Lan-Fang Cao Qing-Bo Xu Li Yang 

机构地区：[1]Department of Endocrinology,Jiangxi Provincial Children’s Hospital/The Affiliated Children’s Hospital of Nanchang Medical College,Nanchang 330038,Jiangxi Province,China

出　　处：《World Journal of Diabetes》2025年第5期148-158,共11页世界糖尿病杂志(英文)

基　　金：Supported by Jiangxi Provincial Health Commission Science and Technology Plan,No.SKJP220212334。

摘　　要：BACKGROUND Early kidney damage is a significant complication in children with newly diagnosed type 1 diabetes mellitus(T1DM).Systemic inflammation plays a key role in the development of diabetic nephropathy.Several inflammatory markers,including the systemic immune inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),and platelet-to-lymphocyte ratio(PLR),have been proposed as potential indicators of diabetic complications.AIM To investigate the association between SII,NLR,PLR,and early kidney damage in newly diagnosed T1DM children without pre-existing albuminuria,assessing their utility as predictive biomarkers.METHODS A longitudinal cohort study was conducted on 102 children aged 3-18 years with newly diagnosed T1DM[baseline urinary albumin-to-creatinine ratio(UACR)<30 mg/g]recruited between January 2020 and June 2023.Participants were followed biannually for up to three years.Demographic,clinical,and laboratory data,including inflammatory markers(SII,NLR,PLR),were collected at baseline and follow-up.Logistic regression and receiver operating characteristic analyses were used to evaluate the predictive utility of these markers for early kidney damage,defined as UACR≥30 mg/g.RESULTS SII emerged as a significant independent predictor of early kidney damage[odds ratio=1.002,95%confidence interval(CI):1.0008-1.0033,P=0.0016],with an area under the curve of 0.719(95%CI:0.612-0.826,P<0.001).Using an SII threshold of≥624.015 achieved a sensitivity of 59.6%and specificity of 92%.Combining SII with NLR and PLR improved predictive accuracy(area under the curve=0.787),with sensitivity and specificity of 63.5%and 96%,respectively.Correlation analyses revealed significant associations between SII,metabolic markers(triglycerides,glycated hemoglobin),and UACR.CONCLUSION SII is a reliable biomarker for early kidney damage in T1DM children,offering high specificity for identifying atrisk patients.Combining SII with NLR and PLR enhances diagnostic precision,supporting its integration into clinical practice.Longitudina

关 键 词：Pediatric type 1 diabetes mellitus Systemic immune inflammation index Kidney injury Urinary albumin-tocreatinine ratio Inflammatory markers 

分 类 号：R725.8[医药卫生—儿科]