L-arginine overdose is a potential risk factor for myocardial injury in patients with type 2 diabetes  

作　　者：Yan Chen Meng-Ting Dai Guo-Hua Gong 

机构地区：[1]School of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Wenzhou 325035,Zhejiang Province,China

出　　处：《World Journal of Diabetes》2025年第5期453-457,共5页世界糖尿病杂志(英文)

基　　金：Supported by The Medical Health Science and Technology Project of Zhejiang Provincial Health Commission,No.2024KY138;The Basic Research Project of Wenzhou Municipal Science and Technology Bureau,No.Y20240008;The Key Discipline of Zhejiang Province in Medical Technology(First Class,Category A);The Key Laboratory of School of Laboratory Medicine and Life Sciences,Wenzhou Medical University of China,No.JS2023003.

摘　　要：We comment on an article published by Mansouri et al in the World Journal of Diabetes.L-arginine(L-Arg),a dietary supplement,is a precursor of nitric oxide,can improve cardiovascular disease,and it is important for treating heart disease and hypertension.Previous studies have demonstrated a beneficial effect of L-Arg on diabetes.In the study by Mansouri et al,L-Arg moderately increased blood glucose levels in normal rats.However,in diabetic rats,L-Arg significantly increased lipid levels,which is different from the findings of previous studies.This study demonstrated that a safe dose of 0.5 g/kg in diabetic rats can improve the lipid profile and decrease body weight.However,high doses(1 g/kg or higher)may aggravate damage to myocardial tissue in diabetic rats by increasing blood glucose,inflammation,and oxidative stress.Therefore,this study further demonstrated that high doses of L-Arg can exacerbate myocardial injury in diabetic patients.

关 键 词：L-ARGININE GLUCOSE Oxidative stress ANTIOXIDANT Inflammation CARDIAC 

分 类 号：R587.1[医药卫生—内分泌]