Personalized therapeutic approaches for improved glycemic outcomes in type 2 diabetes  

作　　者：Eguono Deborah Akpoveta Uchenna E Okpete Haewon Byeon 

机构地区：[1]Department of Community Medicine,Federal Medical Centre,Asaba 322022,Delta state,Nigeria [2]Department of Digital Anti-aging Healthcare(BK21),Inje University,Gimhae 50834,South Korea [3]Department of Future Technology,Korea University of Technology and Education,Cheonan 31253,South Korea

出　　处：《World Journal of Diabetes》2025年第5期458-463,共6页世界糖尿病杂志(英文)

基　　金：Supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,No.NRF-RS-2023-00237287。

摘　　要：Managing type 2 diabetes mellitus remains a significant challenge,particularly for individuals with persistently poor glycemic control.Although inadequate glycemic regulation is a well-established public health concern and a major contributor to diabetes-related complications,evidence on the effectiveness of intensive and supportive interventions across diverse patient subgroups is scarce.This editorial examines findings from a prospective study evaluating the influence of glycemic history on treatment outcomes in poorly controlled diabetes.The study highlights that personalized care models outperform generalized approaches by addressing the unique trajectories of glycemic deterioration.Newly diagnosed patients demonstrated the most favorable response to intervention,while those with consistently elevated glycated hemoglobin(≥10%)faced the greatest challenges in achieving glycemic control.These findings underscore the limitations of a onesize-fits-all strategy,reinforcing the need for patient-centered care that integrates individualized monitoring and timely intervention.Diabetes management requires prioritizing personalized treatment strategies that mitigate therapeutic inertia and ensure equitable,effective care for all patients.

关 键 词：Glycemic trajectories Personalized treatment Diabetes control Therapeutic inertia Glycated hemoglobin improvement Metabolic challenges 

分 类 号：R587.1[医药卫生—内分泌]