时空针灸治疗失眠的疗效观察及对血清褪黑素和5-羟色胺水平的影响  

Observation on the efficacy of space-time acupuncture for insomnia and its effect on serum melatonin and 5-hydroxytryptamine levels

作　　者：刘亮先 王祖红[1] 方永江[1] 郭春艳[1] 王英浩 盘雪娇 普菊华 朱勉生 LIU Liangxian;WANG Zuhong;FANG Yongjiang;GUO Chunyan;WANG Yinghao;PAN Xuejiao;PU Juhua;ZHU Miansheng(Yunnan Kunming Hospital of Traditional Chinese Medicine,Kunming 650500,China;France Paris Academy of Space-Time Acupuncture,Paris 75013,France)

机构地区：[1]云南省昆明市中医医院,昆明650500 [2]法国巴黎时空针灸研究院,巴黎75013

出　　处：《上海针灸杂志》2025年第4期402-406,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：昆明市卫生健康委员会千工程卫生科研课题项目(2021-09-01-001);云南省科技厅云南中医药大学应用基础研究联合专项面上项目(202101AZ070001-089)。

摘　　要：目的 观察时空针灸治疗心肾不交型失眠的临床疗效及对患者血清褪黑素(melatonin, MT)和5-羟色胺(5-hydroxytryptamine,5-HT)水平的影响。方法 将80例心肾不交型失眠患者按随机数字表法分为治疗组和对照组,每组40例。治疗组采用时空针灸灵龟八法治疗,对照组采用常规针刺治疗。观察两组治疗前后匹兹堡睡眠质量指数(Pittsburgh sleep quality index, PSQI)及血清MT和5-HT水平的变化,比较两组临床疗效和不良反应发生情况。结果 治疗后,两组PSQI总分和各单项评分均降低(P<0.05),且治疗组PSQI总分及入睡时间、睡眠时间、睡眠效率和睡眠障碍的单项评分均低于对照组(P<0.05)。治疗后,治疗组血清MT和5-HT水平均较治疗前升高(P<0.05),且治疗组血清MT和5-HT水平均高于对照组(P<0.05),治疗组血清MT和5-HT治疗前后差值均高于对照组(P<0.05)。治疗组总有效率为92.5%,显著高于对照组的77.5%,差异具有统计学意义(P<0.05)。结论 时空针灸治疗失眠的临床疗效优于常规针刺,可有效改善睡眠质量,可能与调节血清MT和5-HT水平有关。Objective To observe the clinical efficacy of space-time acupuncture for insomnia of heart-kidney disharmony type and its effect on serum melatonin(MT)and 5-hydroxytryptamine(5-HT)levels in the patients.Method Eighty patients with insomnia of heart-kidney disharmony type were randomized to a treatment group and a control group,with 40 cases in each group.The treatment group received space-time acupuncture with the eightfold method of the sacred tortoise and the control group,conventional acupuncture.The Pittsburgh sleep quality index(PSQI)and serum MT and 5-HT levels were observed in the two groups before and after treatment.The clinical therapeutic effects and the occurrences of adverse reactions were compared between the two groups.Result After treatment,the PSQI total score and various item scores decreased in the two groups(P<0.05)and the PSQI total score,and the sleep latency,sleep duration,habitual sleep efficiency and sleep disturbances scores were lower in the treatment group than in the control group(P<0.05).After treatment,serum MT and 5-HT levels increased in the treatment group compared with before(P<0.05)and they were higher in the treatment group than in the control group(P<0.05).The pre-/post treatment difference values of serum MT and 5-HT levels were higher in the treatment group than in the control group(P<0.05).The total efficacy rate was 92.5%in the treatment group,which was significantly higher than 77.5%in the control group with a statistically significant difference(P<0.05).Conclusion Space-time acupuncture is clinically more effective than conventional acupuncture in treating insomnia.It can improve sleep quality,which may be related to regulate serum MT and 5-HT levels.

关 键 词：针刺疗法 时空针灸 灵龟八法 睡眠障碍 褪黑素 5-羟色胺 

分 类 号：R246.6[医药卫生—针灸推拿学]