针刺治疗乳腺癌内分泌治疗后心肾不交型汗证的疗效观察  

Observation on the efficacy of acupuncture for hyperhidrosis of heart-kidney disharmony type after endocrine therapy for breast cancer

作　　者：覃霄燕[1] 李鸿章[2] 王洪宇 刘奕兵 白瑞莉[1] QIN Xiaoyan;LI Hongzhang;WANG Hongyu;LIU Yibing;BAI Ruili(Henan Zhengzhou Third People's Hospital,Zhengzhou 450002,China;Henan Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China)

机构地区：[1]河南省郑州市第三人民医院,郑州450002 [2]河南省中医院,郑州450002

出　　处：《上海针灸杂志》2025年第4期429-433,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：河南省科技攻关计划项目(LHGJ20200724);郑州市中医药骨干人才培养项目[郑卫管(2023)25号]。

摘　　要：目的 观察针刺阴郄穴配复溜穴治疗绝经前乳腺癌内分泌治疗后心肾不交型汗证的临床疗效。方法选取绝经前乳腺癌内分泌治疗后心肾不交型汗证患者80例,采用随机对照法分为观察组(40例)和对照组(40例)。研究过程中,观察组2例及对照组1例因未完全遵守试验要求而脱落,最终纳入统计患者77例,观察组38例以及对照组39例。观察组予针刺阴郄配复溜穴治疗,对照组予非穴浅刺的假针刺治疗。观察两组治疗前后中医证候积分、多汗症疾病严重程度量表(hyperhidrosis disease severity scale, HDSS)评分、焦虑自评量表(self-rating anxiety scale, SAS)评分、抑郁自评量表(self-rating depression scale, SDS)评分以及血清激素水平[雌二醇(estradiol, E2)、卵泡刺激素(follicle stimulating hormone, FSH)、黄体生成素(luteinizing hormone, LH)]水平的变化。比较两组临床疗效。结果 观察组总有效率为94.7%,明显高于对照组的56.4%(P<0.05)。观察组治疗后HDSS评分情况优于治疗前(P<0.05),且优于对照组(P<0.05)。治疗后,两组SAS和SDS评分均较治疗前降低(P<0.05),且观察组上述评分低于对照组(P<0.05)。两组治疗前后血清FSH、E2和LH水平比较,差异无统计学意义(P>0.05)。结论 针刺阴郄配复溜穴可有效缓解绝经前乳腺癌内分泌治疗后心肾不交型汗证,可改善抑郁和焦虑状态。Objective To observe the clinical efficacy of acupuncture at combined points Yinxi(HT6)and Fuliu(KI7)for hyperhidrosis of heart-kidney disharmony type after endocrine therapy for premenopausal breast cancer.Method Eighty patients with hyperhidrosis of heart-kidney disharmony type after endocrine therapy for premenopausal breast cancer were allocated,using a randomized controlled method,to an observation group(40 cases)and a control group(40 cases).During the study,two cases dropped out in the observation group and one case,in the control group because they did not completely comply with the study requirements.Finally,77 cases were included for statistical analysis,38 in the observation group and 39 in the control group.The observation group received acupuncture at combined points Yinxi and Fuliu and the control group,sham acupuncture with shallow needling at non-acupoints.The TCM symptom score,the hyperhidrosis disease severity scale(HDSS)score,the self-rating anxiety scale(SAS)score and the self-rating depression scale(SDS)score were recorded and serum hormone[estradiol(E2),follicle stimulating hormone(FSH)and luteinizing hormone(LH)]levels were measured in the two groups before and after treatment.The clinical therapeutic effects were compared between the two groups.Result The total efficacy rate was 94.7%in the observation group,which was significantly higher than 56.4%in the control group(P<0.05).After treatment,the HDSS score was better in the observation group compared with before(P<0.05)and than in the control group(P<0.05).After treatment,the SAS and SDS scores decreased in the two groups compared with before(P<0.05)and were lower in the observation group than in the control group(P<0.05).There were no statistically significant pre-treatment and post-treatment differences in serum E2,FSH and LH levels between the two groups and no statistically significant within-group differences after treatment(P<0.05).Conclusion Acupuncture at combined points Yinxi and Fuliu can effectively alleviate hyperhidrosis of h

关 键 词：针刺疗法 假针刺 汗证 心肾不交 乳腺癌 内分泌治疗 

分 类 号：R246.5[医药卫生—针灸推拿学]