OSTA联合下肢血管粥样硬化对中老年患者骨质疏松风险筛查效果  

Effect of routine admission examination combined with general data on screening the risk of osteoporosis in middle-aged and elderly hospitalized patients

作　　者：陈志平 赵国阳[2] CHEN Zhiping;ZHAO Guoyang(Department of Orthopedics,the Second People’s Hospital of Taizhou Affiliated to Yangzhou University,Taizhou 225500,China;Department Orthopedics,the Affiliated Hospital of Jiangsu University,Zhenjiang 212001,China)

机构地区：[1]扬州大学附属泰州市第二人民医院骨科,江苏泰州225500 [2]江苏大学附属医院骨科,江苏镇江212001

出　　处：《中国骨质疏松杂志》2025年第4期526-529,共4页Chinese Journal of Osteoporosis

基　　金：白求恩公益基金会骨质疏松和骨矿盐疾病中青年医生优才培养计划项目(G-X-2019-1107)。

摘　　要：目的探索能否依据入院常规检查结果及一般资料对中老年住院患者骨质疏松风险进行筛查。方法选取2023年6月至2024年6月因脊柱脆性骨折于泰州市第二人民医院住院治疗的中老年患者。收集患者的人口统计学信息、入院常规检查结果以及骨密度数据,通过组间比较、相关因素二元Logistic回归以及ROC曲线进行统计分析。结果组间比较结果显示,与非骨质疏松组相比,骨质疏松组的身高、亚洲人骨质疏松自我筛查工具(osteoporosis self-assessment tool for Asians,OSTA)、血红蛋白、白蛋白显著降低,下肢动脉粥样硬化阳性率显著增高(P<0.05);二元Logistic回归分析结果显示,OSTA与下肢动脉粥样硬化是骨质疏松症发病的相关因素,OR值分别为8.926和3.971(P<0.05)。ROC曲线结果显示,单独OSTA对骨质疏松风险具有良好的筛查效果(AUC为0.795,P<0.05),OSTA联合下肢血管粥样硬化进一步提高了对骨质疏松风险的筛查效果(AUC为0.835,P<0.05)。结论OSTA与下肢血管粥样硬化在骨质疏松发生、发展中具有相关性。对于中老年患者,可通过由年龄、体重计算而得的OSTA以及入院常规中的下肢血管超声进行骨质疏松风险评估,以达到简便、经济的筛查效果。Objective To explore whether the risk of osteoporosis in middle-aged and elderly hospitalized patients can be screened based on routine admission examination result and general data.Methods Middle-aged and elderly patients hospitalized in the Second People's Hospital of Taizhou City for spinal fragile fractures from June 2023 to June 2024 were selected.Patient demographic information,routine examination result on admission and bone mineral density data were collected,and statistical analysis was performed through inter-group comparisons,binary logistic analysis,and ROC curves.Results The result of inter-group comparisons showed that compared with the non-osteoporotic group,the height,OSTA,hemoglobin,and albumin in the osteoporotic group were significantly lower,and the positive rate of lower limb atherosclerosis(LLA)was significantly higher(P<0.05).The result by binary logistic analysis showed that OSTA(OR=1.609)and LLA(OR=1.002)were related factors of osteoporosis(P<0.05).The result by ROC curve showed that OSTA alone has a good screening effect on the risk of osteoporosis(AUC=0.795,P<0.05),and OSTA combined with LLA further improves the screening effect on the risk of osteoporosis(AUC=0.835,P<0.05).Conclusion OSTA and lower limb atherosclerosis were associated with osteoporosis.For middle-aged and elderly patients,osteoporosis risk assessment can be performed through OSTA calculated based on age and weight,and lower limb vascular ultrasound during admission to achieve a simple and economical screening effect.

关 键 词：骨质疏松症 下肢动脉粥样硬化 亚洲人骨质疏松自我筛查工具 骨密度 中老年 

分 类 号：R589.5[医药卫生—内分泌] R543[医药卫生—内科学]