维持性血液透析患者血清钙、磷水平与骨质疏松发生的相关性分析  

Analysis of the correlation between serum calcium and phosphorus levels and the occurrence of osteoporosis in patients under maintenance hemodialysis

作　　者：袁燕 郭利敏 郭珊 YUAN Yan;GUO Limin;GUO Shan(Xinxiang Central Hospital,Xinxiang Medical University Fourth Clinical College,Xinxiang 453000,He′nan,China)

机构地区：[1]新乡市中心医院新乡医学院第四临床学院,河南新乡453000

出　　处：《中国骨质疏松杂志》2025年第4期540-543,557,共5页Chinese Journal of Osteoporosis

摘　　要：目的探讨维持性血液透析患者血清钙、磷水平与骨质疏松发生的相关性。方法以回顾性分析选择114例维持性血液透析患者纳入研究,为观察组;另选择同期体检的健康受试者114例为对照组。参考骨质疏松诊断标准,将观察组分为骨质疏松组(n=50)、非骨质疏松组(n=64),分别检测两组患者骨密度值、血清钙以及磷水平,比较两组患者血清钙、磷水平,借助受试者工作特征曲线分析血清钙、磷水平对维持性血液透析患者骨质疏松的诊断价值,以Pearson分析血清钙、磷水平与骨质疏松发生的相关性。结果观察组血清钙低于对照组、血清磷水平高于对照组(P<0.05)。骨质疏松组钙水平更低,但组间对比差异无统计学意义(P>0.05);两组患者血清磷水平比较差异具有统计学意义(P<0.05)。与单一血清钙、磷检测相比,联合指标的诊断价值更高,其灵敏度、特异性分别为80.00%、96.90%,均高于单一检测。血清钙水平与患者骨质疏松严重程度呈反比,血清磷水平与患者骨质疏松严重程度呈正比。结论维持性血液透析患者,采用血清钙、磷联合检测对其出现骨质疏松的预测价值更高,能够为临床在维持性血液透析患者骨质疏松诊断中提供数据参考。Objective To explore the correlation between serum calcium and phosphorus levels and the occurrence of osteoporosis in maintenance hemodialysis patients.Methods With retrospective analysis,114 cases of maintenance hemodialysis patients were selected to be included in the study,as the observation group.Meanwhile,114 cases of healthy subjects who underwent physical examination in the same period were selected as the control group.Referring to the diagnostic standard of osteoporosis,patients in the observation group were divided into osteoporosis group(n=50)and non-osteoporosis group(n=64).Bone mineral density and serum calcium and phosphorus levels of patients in the two groups were detected.Serum calcium and phosphorus levels were compared between the two groups.The diagnostic value of serum calcium and phosphorus levels for osteoporosis of the patients under maintenance hemodialysis was analyzed with the help of the working characteristic curves of the subjects and Pearson analysis.The correlation between serum calcium and phosphorus levels and the occurrence of osteoporosis was analyzed with Pearson's analysis.Results Serum calcium level was lower and serum phosphorus level was higher in the observation group than those in the control group(P<0.05).Calcium levels were lower in the osteoporosis group,but there was no difference compared with those between the groups(P>0.05).The difference in serum phosphorus levels between the two groups was significant(P<0.05).The diagnostic value of the combined index was higher than the single serum calcium and phosphorus test,and the sensitivity and specificity were 80.00%and 96.90%,respectively.The serum calcium level was negatively correlated with the severity of osteoporosis.The serum phosphorus level was positively correlated with the severity of osteoporosis.Conclusion In maintenance hemodialysis patients,the use of combined serum calcium and phosphorus testing has a higher predictive value for the development of osteoporosis.This provides clinical data for the reference

关 键 词：维持性血液透析 血清钙 血清磷 骨质疏松 

分 类 号：R55[医药卫生—血液循环系统疾病]