RANKL/RANK/OPG信号通路对双硫死亡影响机制研究  

Mechanism study of the effect of RANKL/RANK/OPG signaling pathway on disulfidptosis

作　　者：马小成 曹林忠[1,2] 拦玉鑫 刘德孙 胡康一 MA Xiaocheng;CAO Linzhong;LAN Yuxin;LIU Desun;HU Kangyi(Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;The Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃中医药大学附属医院,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2025年第4期604-608,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(82160915,81860859);兰州市科技局项目(2022-3-23)。

摘　　要：双硫死亡是二硫键应激引发的一种由于二硫键细胞内积累导致肌动蛋白细胞骨架崩溃,导致细胞死亡的新型细胞死亡形式。研究发现双硫死亡与RANKL/RANK/OPG信号通路密切相关,但其具体机制尚未明确。笔者以RANKL/RANK/OPG信号通路对双硫死亡的发生机制的影响进行阐述,对其关系进行总结,为防治骨代谢相关疾病提供新途径。Disulfidptosis is a novel form of cell death caused by intracellular accumulation of disulfide bonds due to disulfide bond stress,leading to collapse of the actin cytoskeleton and cell death.Studies have found that double sulfide death is closely related to the RANKL/RANK/OPG signaling pathway.However,the specific mechanism is not clear.This article discusses the influence of the RANKL/RANK/OPG signaling pathway in the occurrence of double sulfide death,summarizes the relationship between them,and provides a new approach for the prevention and treatment of bone metabolism-related diseases.

关 键 词：双硫死亡 RANKL/RANK/OPG信号通路 SLC7A11 NFATc1 

分 类 号：R681[医药卫生—骨科学]