从“骨玄府-骨络-髓”论治骨质疏松症及BMSCs归巢、分化  

Exploration of the regulation of osteoporosis-related bone marrow mesenchymal stem cell homing and differentiation based on the theory of bone Xuanfu-bone collateral-marrow

作　　者：吕浩 王久香 胡芷苜 王岩 江渟 LV Hao;WANG Jiuxiang;HU Zhimu;WANG Yan;JIANG Ting(The First Clinical Medical College of Anhui University of Chinese Medicine,Hefei 230031,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China)

机构地区：[1]安徽中医药大学第一临床医学院,安徽合肥230031 [2]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《中国骨质疏松杂志》2025年第4期614-617,624,共5页Chinese Journal of Osteoporosis

基　　金：安徽省自然科学基金项目(面上项目)(2308085MH294);安徽省重点研究与计划开发项目(202104j07020010);安徽省教育厅自然科学研究(重点项目)(2022AH050510)。

摘　　要：骨质疏松症(osteoporosis,OP)是一种常见的代谢性骨病。OP病理机制涉及多个环节,骨髓间充质干细胞(bone mesenchymal stem cells,BMSCs)归巢及分化紊乱会引起OP,阻止其紊乱是防治OP的一个方向。目前中药可协同发挥多环节、多靶点的整合效应,但中医诊治思路常重整体和宏观而轻微观。笔者将从“骨玄府-骨络-髓”理论模型入手探讨BMSCs归巢、分化及OP骨代谢紊乱的分子机制,旨在丰富OP的病因病机,以期为该病的治疗提供参考。并将传统的中医理论与现代医学相结合,从微观物质视角探索中医理论的科学内涵。Osteoporosis(OP)is a common metabolic bone disease.The pathological mechanism of OP involves multiple processes.The dysregulation of bone mesenchymal stem cells(BMSCs)homing and differentiation may lead to OP,making its prevention and treatment a potential target.Currently,traditional Chinese medicine(TCM)exerts an integrated effect on multiple processes and targets.However,the diagnosis and treatment of TCM often focus more on the holistic and macroscopic aspects rather than the microscopic.Therefore,this paper aims to explore the molecular mechanism of BMSCs homing,differentiation,and bone metabolic disorders in OP from the theoretical model of bone Xuanfu-bone collateral-marrow theory.The purpose is to enrich the etiology and pathogenesis of OP and to provide a reference for the treatment of this disease.By combining traditional TCM theory with modern medicine,we seek to explore the scientific implications of TCM theory from a microscopic material perspective.

关 键 词：骨质疏松症 骨髓间充质干细胞 骨玄府-骨络-髓 归巢 分化 

分 类 号：R255.6[医药卫生—中医内科学] R580[医药卫生—中医学]