烟酰胺单核苷酸在骨质疏松中的作用及机制研究进展  

Research progress in the mechanism of nicotinamide mononucleotide in osteoporosis

作　　者：庞永杰 王新扬 武艺[1,2] 唐汉琴 高玉海 陈克明[1,2] PANG Yongjie;WANG Xinyang;WU Yi;TANG Hanqin;GAO Yuhai;CHEN Keming(Basic Medical Laboratory,the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army,Lanzhou 730050,China;Key Laboratory of Stem Cells and Gene Drug of Gansu Province,Lanzhou 730050,China)

机构地区：[1]中国人民解放军联勤保障部队第九四○医院基础医学实验室,甘肃兰州730050 [2]甘肃省干细胞与基因药物重点实验室,甘肃兰州730050

出　　处：《中国骨质疏松杂志》2025年第4期618-624,共7页Chinese Journal of Osteoporosis

基　　金：兰州市科技计划项目(2023-1-8,2023-ZD-183);甘肃省自然科学基金项目(22JR11RA013);联勤保障部队第940医院G计划人才项目(2024-G3-10)。

摘　　要：烟酰胺单核苷酸(nicotinamide mononucleotide,NMN)是维生素B3的一种衍生物,人体内稳定的内在物质。作为一种关键的天然烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide,NAD^(+))中间体,可有效促进间充质干细胞(mesenchymal stem cells,MSCs)、成骨细胞的增殖分化,抑制破骨细胞活性,从而提高成骨作用,减少骨质流失。笔者综述了近年来NMN在骨代谢中的调控机制、预防骨质疏松及加速骨折骨愈合的研究进展,为后续骨质疏松的基础研究与治疗提供参考。Nicotinamide mononucleotide(NMN)is a derivative of vitamin B3 and a stable intrinsic substance in the human body.As a key natural nicotinamide adenine dinucleotide(NAD)intermediate,NMN effectively promotes the proliferation and differentiation of mesenchymal stem cells(MSCs)and osteoblasts,inhibits the activity of osteoclasts,thereby improves osteogenesis and reduces bone loss.In this review,the regulation mechanism of NMN in bone metabolism,prevention of osteoporosis,and acceleration of bone healing in recent years is reviewed,which may provide reference for the follow-up basic research and treatment of osteoporosis.

关 键 词：烟酰胺单核苷酸 骨质疏松 骨代谢 间充质干细胞 

分 类 号：R681[医药卫生—骨科学]