解毒祛瘀片联合负压封闭引流技术治疗肢体创伤后感染性创面的临床研究  

Clinical Efficacy of Jiedu Quyu Tablets Combined with Vacuum Sealing Drainage Technique in Treating Infected Wounds after Limb Trauma

作　　者：任书朋 詹晓欢 王朝辉[1] 张家盛[1] 卢伟 郭盈澳 Ren Shupeng;Zhan Xiaohuan;Wang Zhaohui;Zhang Jiasheng;Lu Wei;Guo Yingao(The Eighth Clinical Medical College of Guangzhou University of Traditional Chinese Medicine,Foshan Hospital of Traditional Chinese Medicine,Guangdong,Foshan 528000,China)

机构地区：[1]广州中医药大学第八临床医学院,佛山市中医院,广东佛山528000 [2]广州中医药大学第四临床医学院,深圳市中医院,广东深圳510006

出　　处：《中国中医急症》2025年第4期611-615,共5页Journal of Emergency in Traditional Chinese Medicine

基　　金：广东省基础与应用基础研究基金项目(2022A1515220061);佛山市重点领域科技攻关项目(2020001006106)。

摘　　要：目的观察解毒祛瘀片联合负压封闭引流技术(VSD)修复肢体创伤后感染性创面的临床疗效及对患者自身血清炎性因子水平的影响。方法将62例肢体创伤后创面感染患者按照治疗方式不同分为观察组与对照组,在均进行清创、换药及对症治疗的基础上,对照组患者接受VSD技术治疗,观察组患者给予解毒祛瘀片联合VSD技术治疗,比较治疗后2周两组患者创面愈合优良率、治疗时间、并发症发生情况、治疗前后视觉模拟量表(VAS)评分以及治疗后1周自身血清炎性因子水平。结果治疗后2周,观察组患者的创面修复优良率高于对照组(P<0.05);观察组患者的创面愈合时间、感染消失时间、抗生素使用时间、住院时间均短于对照组(P<0.05);两组患者的超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、淀粉样蛋白(SAA)、血沉(ESR)水平在治疗后1周均降低,且观察组更低(P<0.05)。结论在负压封闭引流技术治疗肢体创伤后感染性创面的基础上辅以解毒祛瘀片效果显著,能有效改善临床症状及自身血清炎性因子水平。Objective:To observe the clinical efficacy of Jiedu Quyu Tablets combined with Vacuum Sealing Drainage(VSD)technique in repairing infected wounds after limb trauma and its impact on serum inflammatory factor levels in patients.Methods:62 patients with post-traumatic infected wounds were divided into an observation group and a control group based on different treatment methods.Both groups received debridement,dressing changes,and symptomatic treatment.The control group was treated with VSD technique,while the observation group received Jiedu Quyu Tablets combined with VSD technique.2 weeks after treatment,the wound healing excellence rate,treatment duration,complication occurrence,VAS scores before and after treatment,and serum inflammatory factor levels one week after treatment were compared between the two groups.Results:2 weeks after treatment,the excellent healing rate of wounds in the observation group was significantly higher than that in the control group(P<0.05).The wound healing time,infection clearance time,antibiotic usage time,and hospital stay in the observation group were all shorter than those in the control group(P<0.05).One week after treatment,the levels of hypersensitive C-reactive protein(hs-CRP),procalcitonin(PCT),serum amyloid A(SAA),and erythrocyte sedimentation rate(ESR)in both groups decreased,with lower levels observed in the observation group.Conclusion:The addition of Jiedu Quyu Tablets to VSD technique for treating infected wounds after limb trauma is highly effective,which can significantly improve clinical symptoms and serum inflammatory factor levels.

关 键 词：肢体创伤感染性创面 负压封闭引流术 解毒祛瘀片 血清炎性因子 

分 类 号：R63[医药卫生—外科学]