应用斑马鱼模型评价紫檀芪的护肤功效  

Skincare Efficacy of Pterostilbene Using Zebrafish as Model

作　　者：岑宗晓 陈智远 王丁 陈雪平 陈均源 CEN Zongxiao;CHEN Zhiyuan;WANG Ding;CHEN Xueping;CHEN Junyuan(Guangzhou Luanying Cosmetics Co.,Ltd.,Guangzhou 510200,Guangdong,China;Centre for Biotech Big Data Research&Development,Research Institute of Tsinghua,Pearl River Delta,Guangzhou,510200,Guangdong,China;Vitargent(International)Biotechnology Limited,Hong Kong Science Park,Hong Kong SAR 999077,China)

机构地区：[1]广州銮滢化妆品有限公司,广东广州510200 [2]清华珠三角研究院生物大数据研发中心,广东广州510200 [3]水中银(国际)生物科技有限公司,中国香港999077

出　　处：《香料香精化妆品》2025年第2期85-91,共7页Flavour Fragrance Cosmetics

摘　　要：通过测定紫檀芪对斑马鱼胚胎体内活性氧(ROS)、侧线区域中性粒细胞数目、晚期糖基化终末产物(AGEs)、衰老相关β-半乳糖苷酶(SA-β-gal)、尾鳍再生长度、体节间血管(ISV)新生长度、血液循环速度、血管宽度和皮肤失水等指标的影响,以评价紫檀芪的护肤功效。结果显示,紫檀芪能显著(P<0.05)降低ROS水平、抑制硫酸铜诱导的侧线区域中性粒细胞聚集、减低过氧化叔丁醇诱导的SA-β-gal水平、抑制AGEs生成、改善索拉非尼抑制的Tg(kdrl:EGFP)斑马鱼ISV新生、加速切除的尾鳍再生、促进背主动脉血液流动速度、扩张背主动脉血管和减低皮肤水分流失。因此,紫檀芪具有很好的抗衰老护肤功效。The effects of pterostilbene on reactive oxygen species(ROS),neutrophil aggregation,senescence-associatedβ-galactosidase(SA-β-gal),advanced glycation end products(AGEs),tail fin wound healing,intersegmental blood vessel(ISV)regeneration,blood circulation speed,dorsal aorta width,and skin water loss were investigated using zebrafish embryo as model organism.The results showed that pterostilbene significantly(P<0.05)reduced ROS,SA-β-gal(induced by tert-butyl hydroperoxide)and AGEs,improved ISV regeneration after sorafenib treatment and tail fin regeneration after amputation,enhanced blood circulation speed in dorsal aorta,enlarged dorsal aorta width,and prevented skin water loss.All these results demonstrated the promising antiaging skincare efficacy of pterostilbene.

关 键 词：紫檀芪 斑马鱼 抗氧化 抗衰老 

分 类 号：R285.5[医药卫生—中药学]