脂蛋白与冠心病冠脉病变严重程度及短期预后的相关性研究  

Association Between Lipoprotein and the Severity of Coronary Artery Lesions and Short-Term Prognosis in Coronary Heart Disease

作　　者：张福生 杨晖 曾志良 ZHANG Fusheng;YANG Hui;ZENG Zhiliang(Ruijin City People's Hospital,Ruijin 342500,China)

机构地区：[1]瑞金市人民医院,江西瑞金342500

出　　处：《延边大学医学学报》2025年第3期91-93,共3页Journal of Medical Science Yanbian University

基　　金：赣州市科技计划项目(编号:GZ2023ZSF566)。

摘　　要：目的:分析脂蛋白与冠心病冠脉病变严重程度及短期预后的相关性。方法:选择2022年3月—2023年6月于瑞金市人民医院心内科住院行冠状动脉造影检查的冠心病患者304例(男200例,女104例),患者年龄40~90岁,根据冠脉造影检查结果分为低积分组(n=104)、中积分组(n=100)、高积分组(n=100),比较三组脂蛋白a水平、冠心病冠脉病变危险因素。根据预后情况分为预后良好组(n=204)与预后不良组(n=100),比较预后良好组与预后不良组冠心病冠脉病变患病率。结果:低积分组、中积分组与高积分组年龄、吸烟率、高血压患病率、糖尿病患病率、高脂蛋白a患病率、空腹血糖(FBG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、脂蛋白a水平比较差异有统计学意义(P<0.05);预后不良组、预后良好组冠心病患病率、高血压患病率、脂蛋白a、HDL-C水平比较差异有统计学意义(P<0.05);相关性分析显示,脂蛋白a水平越高,冠心病冠脉病变严重程度越高,两者呈正相关性(r=9.011,P<0.001)。结论:脂蛋白a水平可作为评估冠心病冠脉病变患者冠脉病变严重程度及预后的指标。Objective:To analyze the correlation between lipoprotein(Lp)and the severity of coronary artery lesions as well as short-term prognosis in patients with coronary heart disease(CHD).Methods:A total of 304 CHD patients(200 males and 104 females,aged 40-90 years)who underwent coronary angiography at Ruijin City People's Hospital from March 2022 to June 2023 were enrolled.Based on coronary angiography results,patients were divided into low-score(n=104),medium-score(n=100),and high-score(n=100)groups.Lp(a)levels and coronary risk factors were compared among the three groups.Patients were further categorized into favorable prognosis(n=204)and poor prognosis(n=100)groups to compare the prevalence of coronary lesions.Results:Statistically significant differences(P<0.05)were observed among the three groups in age,smoking rate,prevalence of hypertension,diabetes,elevated Lp(a),fasting blood glucose(FBG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),and Lp(a)levels.Significant differences(P<0.05)were also found between prognosis groups in coronary lesion prevalence,hypertension,elevated Lp(a),and HDL-C levels.Correlation analysis revealed a positive association between higher Lp(a)levels and increased severity of coronary lesions(r=9.011,P<0.001).Conclusion:Lp(a)levels may serve as an indicator for evaluating the severity of coronary lesions and short-term prognosis in CHD patients.

关 键 词：冠心病冠脉病变 脂蛋白A 严重程度 短期预后 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]