自体富血小板血浆在甲状腺结节消融治疗中的应用效果研究  

Study on the Application Effect of Autologous Platelet-Rich Plasma in the Ablation Therapy of Thyroid Nodules

作　　者：裴鹏昌 李家曾 黄兆志 PEI Pengchang;LI Jiazeng;HUANG Zhaozhi(The Eighth People's Hospital of Nanning,Nanning 530012,China)

机构地区：[1]南宁市第八人民医院,广西南宁530012

出　　处：《延边大学医学学报》2025年第3期97-100,共4页Journal of Medical Science Yanbian University

基　　金：广西壮族自治区卫生健康委自筹经费科研课题(编号:Z-A20241105)。

摘　　要：目的:探讨自体富血小板血浆(PRP)在甲状腺结节消融治疗中的应用效果。方法:在2024年3月至11月收治的甲状腺结节患者中,筛选出60例作为研究对象。运用随机分组法分为两组,每组各30例。对照组采用传统消融方案治疗,观察组在此基础上联合自体PRP治疗,对两组的临床治疗效果展开比较与分析。结果:术后1个月、3个月,两组甲状腺功能指标对比(P>0.05)。而术后1个月,观察组的C反应蛋白(CRP)、白细胞介素-6(IL-6)与肿瘤坏死因子-α(TNF-α)水平较对照组明显更低(P<0.05),白细胞介素-10(IL-10)、转化生长因子-β(TGF-β)水平以及细胞增殖活性则显著高于对照组(P<0.05),细胞凋亡率低于对照组(P<0.05)。同时,观察组结节缩小≥50%的比例和症状缓解率均显著高于对照组(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。随访3个月,两组均没有发生甲状腺功能减退、神经损伤等并发症。结论:将自体PRP应用于甲状腺结节消融治疗中,能显著提高患者治疗效果,促进组织修复和再生,改善预后,为甲状腺结节的治疗提供了新思路和方法,具有临床应用价值。Objective:To investigate the application effect of autologous platelet-rich plasma(PRP)in the ablation therapy of thyroid nodules.Methods:Sixty patients with thyroid nodules admitted between March and November 2024 were selected as study subjects and randomly divided into two groups(30 cases each).The control group received traditional ablation therapy,while the observation group was treated with autologous PRP combined with ablation therapy.The clinical efficacy of the two groups was compared and analyzed.Results:At 1 and 3 months postoperatively,there were no significant differences in thyroid function indicators between the two groups(P>0.05).However,at 1 month postoperatively,the observation group exhibited significantly lower levels of CRP,IL-6,and TNF-α,as well as a lower apoptosis rate,compared to the control group.Meanwhile,levels of IL-10,TGF-β,and cell proliferation activity were significantly higher in the observation group(P<0.05).Additionally,the proportion of patients with nodule volume reduction≥50%and symptom relief rate in the observation group were significantly higher than those in the control group(P<0.05).There was no statistically significant difference in adverse reaction rates between the two groups(P>0.05).No complications such as hypothyroidism or nerve injury occurred in either group during the 3-month follow-up.Conclusion:The application of autologous PRP in thyroid nodule ablation therapy can significantly enhance therapeutic efficacy,promote tissue repair and regeneration,improve patient prognosis,and provide new insights and methods for thyroid nodule treatment,demonstrating clinical value.

关 键 词：甲状腺结节 消融治疗 自体富血小板血浆 

分 类 号：R581[医药卫生—内分泌]