哌拉西林钠他唑巴坦钠联合盐酸氨溴索治疗老年肺炎的临床疗效研究  

Clinical Efficacy of Piperacillin Sodium and Tazobactam Sodium Combined with Ambroxol Hydrochloride in the Treatment of Elderly Pneumonia

作　　者：冯少莹 卢景涛 卢允健 FENG Shaoying;LU Jingtao;LU Yunjian(Department of Pharmacy,Guangzhou Panyu District Fifth People’s Hospital,Guangzhou 511495,China;Department of Internal Medicine,Guangzhou Panyu District Fifth People’s Hospital,Guangzhou 511495,China)

机构地区：[1]广州市番禺区第五人民医院药剂科,广东广州511495 [2]广州市番禺区第五人民医院内科,广东广州511495

出　　处：《延边大学医学学报》2025年第3期101-103,共3页Journal of Medical Science Yanbian University

摘　　要：目的:探讨哌拉西林钠他唑巴坦钠联合盐酸氨溴索治疗老年肺炎的疗效。方法:选择2021年4月—2023年8月在广州市番禺区第五人民医院接受治疗的100例老年肺炎患者作为研究对象,以随机数字表法分为两组,其中常模组(50例)使用盐酸氨溴索治疗,研讨组(50例)使用哌拉西林钠他唑巴坦钠联合盐酸氨溴索治疗。对比两组的临床疗效、症状体征消失时间、炎性因子水平、血气指标及肺功能指标。结果:研讨组治疗总有效率高于常模组(P<0.05)。研讨组肺部啰音、发绀、水肿、气促消失时间均比常模组短(P<0.05)。治疗后,研讨组各炎性因子水平均比常模组低(P<0.05)。治疗后,研讨组用力肺活量(FVC)比常模组高(P<0.05),动脉血二氧化碳分压(PaCO_(2))比常模组低(P<0.05)。结论:哌拉西林钠他唑巴坦钠联合盐酸氨溴索治疗老年肺炎能够提高患者的临床疗效,值得推广。Objective:To investigate the efficacy of piperacillin sodium and tazobactam sodium combined with ambroxol hydrochloride in treating elderly pneumonia.Methods:A total of 100 elderly pneumonia patients admitted to Guangzhou Panyu District Fifth People’s Hospital from April 2021 to August 2023 were selected and divided into two groups using the random number table method.The control group(50 cases)received ambroxol hydrochloride alone,while the study group(50 cases)received piperacillin sodium and tazobactam sodium combined with ambroxol hydrochloride.Clinical efficacy,symptom/sign resolution time,inflammatory factor levels,blood gas indicators,and pulmonary function were compared between the two groups.Results:The total effective rate in the study group was higher than that in the control group(P<0.05).The disappearance times of lung rales,cyanosis,edema,and dyspnea in the study group were shorter than those in the control group(P<0.05).After treatment,inflammatory factor levels in the study group were lower than those in the control group(P<0.05).Post-treatment forced vital capacity(FVC)in the study group was higher,while arterial partial pressure of carbon dioxide(PaCO_(2))was lower compared to the control group(P<0.05).Conclusion:The combination of piperacillin sodium and tazobactam sodium with ambroxol hydrochloride improves clinical efficacy in elderly pneumonia patients and is worthy of promotion.

关 键 词：肺炎 老年人 哌拉西林钠他唑巴坦钠 盐酸氨溴索 炎性因子 血气指标 肺功能 

分 类 号：R563.1[医药卫生—呼吸系统]