微波消融肺组织的离体实验与有限元仿真  

Ex vivo Experiment and Finite Element Simulation of Microwave Ablation on Lung Tissue

作　　者：吴水才[1] 刘菊 张宇博 高宏建[1] WU Shuicai;LIU Ju;ZHANG Yubo;GAO Hongjian(Faculty of Environment and Life,Beijing University of Technology,Beijing 100124,China)

机构地区：[1]北京工业大学环境与生命学部,北京100124

出　　处：《北京工业大学学报》2025年第5期625-636,共12页Journal of Beijing University of Technology

基　　金：国家自然科学基金资助项目(61871005)。

摘　　要：为了研究肺组织微波消融(microwave ablation,MWA)的真实效果,基于有限元方法构建了有效的肺组织MWA仿真模型,利用离体猪肺消融实验验证了该模型的精确性,并对不同消融参数的影响进行了深入分析。结果表明,在40 W功率下,设定温度点的平均测量值与仿真结果的误差分别为2.87、2.64和2.99℃,在50 W功率下,误差分别为1.77、2.90和3.20℃,均在临床可接受范围之内。由Arrhenius模型表征的凝固区大小与实验结果具有较好的一致性,长径和短径误差均维持在5 mm以内。设定点的凝固时间和凝固程度随微波功率而变化。另外,凝固区随微波功率和消融时间的增加而显著地增大,但其增长速率并非完全相同。该研究获得了真实可靠的肺消融仿真模型,从而可为临床应用提供参考数据。To study the real effect of microwave ablation(MWA)of lung tissue,an effective simulation model of lung tissue MWA was constructed with finite element method,and the accuracy of the model was verified by ex vivo ablation experiment of porcine lung.At the same time,the effects of different ablation parameters were analyzed in detail.Results show that the errors between the average measured value at the set point and the simulation results are 2.87,2.64 and 2.99℃ at the power of 40 W,respectively,and the errors are 1.77,2.90 and 3.20℃at the power of 50 W,respectively,which are all within the clinically acceptable range.The size of the coagulation zone characterized by the Arrhenius model agrees well with the experimental results,and the errors of long diameter and short diameter are kept within 5 mm.The necrotic time and degree at the set point vary with the microwave power.Additionally,the coagulation zone increases significantly with the increase of the microwave power and ablation time,however,the growth rate is not exactly the same.In this study,a real and reliable simulation model of lung ablation is obtained,which can provide reference data for clinical application.

关 键 词：肺组织 微波消融(MWA) 离体实验 有限元仿真 温度分布 凝固区 

分 类 号：R318[医药卫生—生物医学工程]