丹酚酸B对冠状动脉粥样硬化性心脏病的作用机制研究进展  

Research advances in mechanism of salvianolic acid B in treating coronary heart disease

作　　者：曹洪鸣 孙晖[1] 刘畅[1] 闫广利[1] 孔玲[1] 韩莹[1] 王喜军[1] CAO Hong-ming;SUN Hui;LIU Chang;YAN Guang-li;KONG Ling;HAN Ying;WANG Xi-jun(Chinmedomics Research Center of National Administration of Traditional Chinese Medicine,State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学经方与现代中药融合创新全国重点实验室国家中医药管理局中医方证代谢组学研究中心,黑龙江哈尔滨150040

出　　处：《中国中药杂志》2025年第6期1449-1457,共9页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金青年科学基金项目(82304709)。

摘　　要：冠心病是一种影响冠状动脉的心血管疾病,在全世界呈现出高发病率、高病死率的特点,给人类的生命健康和生活质量带来了严重威胁。唇形科植物丹参被广泛用于以冠心病为代表的心血管疾病的治疗中,丹酚酸B是丹参提取物中的活性成分,研究表明丹酚酸B具有抗炎、抗氧化、影响细胞凋亡、调节细胞自噬、抑制细胞纤维化及调节代谢等功能。该文就近10年来丹酚酸B对冠心病治疗作用的研究进展进行综述,从抑制血栓形成、改善血液循环、减轻心肌细胞损伤和抑制心脏重构等多角度阐述丹酚酸B对冠心病的作用及作用机制。为含有丹酚酸B的中药及其组方在治疗冠心病方面的应用提供了理论依据。Coronary heart disease is a cardiovascular disease that affects coronary arteries.It presents high incidence and high mortality worldwide,bringing a serious threat to human health and quality of life.Salviae Miltiorrhizae Radix et Rhizoma derived from Salvia miltiorrhiza is widely used in the treatment of cardiovascular diseases,such as coronary heart disease.Salvianolic acid B is an active component in Salviae Miltiorrhizae Radix et Rhizoma extracts,and studies have shown that it has anti-inflammatory,antioxidant,apoptosis-and autophagy-regulating,anti-fibrosis,and metabolism-modulating effects.This article reviews the research progress regarding the therapeutic effect of salvianolic acid B on coronary heart disease in the recent decade.It elaborates on the role and mechanism of salvianolic acid B in treating coronary heart disease from multiple perspectives,such as the inhibition of thrombosis,improvement of blood circulation,reduction of myocardial cell injury,and inhibition of cardiac remodeling.This article provides a theoretical basis for the application of Chinese medicinal materials and TCM prescriptions containing salvianolic acid B in the treatment of coronary heart disease.

关 键 词：丹酚酸B 丹参 冠心病 血栓 心肌损伤 

分 类 号：R285[医药卫生—中药学]