白芍中鞣酸类成分的药理作用及作用机制  

Pharmacological effect and mechanism of tannic acids in Paeoniae Radix Alba

作　　者：刁家鑫 郑琪潼 陈孟尧 洪江川 郝敏 冯庆梅 胡军旗[3] 桑夏楠 曹岗[1] DIAO Jia-xin;ZHENG Qi-tong;CHEN Meng-yao;HONG Jiang-chuan;HAO Min;FENG Qing-mei;HU Jun-qi;SANG Xia-nan;CAO Gang(School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 311402,China;College of Chemical and Biological Engineering,Xingtai University,Xingtai 054000,China;Department of Respiratory and Critical Care Medicine,Zhejiang Provincial Hospital of Chinese Medicine,Hangzhou 311402,China)

机构地区：[1]浙江中医药大学药学院,浙江杭州311402 [2]邢台学院化学工程与生物技术学院,河北邢台054000 [3]浙江省中医院呼吸与危重症医学科,浙江杭州311402

出　　处：《中国中药杂志》2025年第6期1471-1483,共13页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(82274101,82374123);浙江省自然科学基金项目(LY24H280002);河北省自然科学基金青年项目(H2023108006);浙江省新苗计划项目(2024R410A0324)。

摘　　要：白芍的化学成分结构类型复杂,主要次级代谢物包括单萜类、鞣质类、三萜类及黄酮类等成分。前期在白芍的物质基础研究中发现,除研究广泛关注的特征性成分单萜苷类化合物外,鞣酸类成分在白芍的药效中也发挥着重要作用,但其药理作用尚未深入研究。该文汇总了国内外关于白芍中鞣酸类成分五没食子酰葡萄糖(PGG)、四没食子酰葡萄糖(TGG)、三没食子酰葡萄糖(TriGG)、没食子酸等鞣酸的结构与性质及特征,并详细阐述其药理活性及其相关机制,以期为白芍的物质基础研究及临床应用提供理论依据。The chemical composition of Paeoniae Radix Alba(PRA)is complex,with primary secondary metabolites including monoterpenoids,tannins,triterpenoids,and flavonoids.In previous studies on the material basis of PRA,it was found that,in addition to the widely studied characteristic monoterpene glycosides,tannic acid components also play an important role in the efficacy of PRA.However,their pharmacological effects have not been thoroughly investigated.This paper reviews the tannic acid components in PRA,including pentagaloyl glucose(PGG),tetragaloyl glucose(TGG),trigaloyl glucose(TriGG),and gallic acid,along with their structures,properties,and characteristics to provide a detailed discussion of their pharmacological activities and related mechanisms,aiming to offer a theoretical basis for the material basis research and clinical application of PRA.

关 键 词：白芍 鞣酸类 结构与性质 药理活性 机制 

分 类 号：R285[医药卫生—中药学]