中药对结直肠癌有氧糖酵解影响的研究进展  

Research progress in effect of traditional Chinese medicine on aerobic glycolysis in colorectal cancer

作　　者：马旭 李生龙 郑光荣 田大成 卢刚刚 高杰 安瑜琪 曹丽媛 李亮[2] 唐晓勇[2] MA Xu;LI Sheng-long;ZHENG Guang-rong;TIAN Da-cheng;LU Gang-gang;GAO Jie;AN Yu-qi;CAO Li-yuan;LI Liang;TANG Xiao-yong(School of Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of General Surgery,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000 [2]甘肃省中医院普外科,甘肃兰州730050

出　　处：《中国中药杂志》2025年第6期1496-1506,共11页China Journal of Chinese Materia Medica

基　　金：甘肃省自然科学基金项目(23JRRA1240,22JR5RA616);甘肃省卫生健康行业科研计划项目(GSWSKY2021-036);甘肃省中医特色优势专科建设项目(甘卫中医函[2022]50号);甘肃省肠梗阻专科联盟建设项目(甘卫医政函[2021]132号)。

摘　　要：结直肠癌(CRC)是全球范围内一种极为常见的恶性肿瘤,患者存在的治疗不耐受、不良反应显著等问题,使其发病率与病死率均位于各类癌症的前列。因此,开辟新的治疗途径对CRC的诊治具有重要意义。有氧糖酵解(AEG)在CRC等肿瘤细胞的微环境形成、细胞增殖、转移和复发中有重要作用,干预AEG途径被证实能有效遏制CRC。中药有效成分和复方能够通过调节与AEG相关的转运蛋白[如葡萄糖转运蛋白(GLUT)]、关键酶[己糖激酶(HK)、磷酸果糖激酶(PFK)等]、关键基因[缺氧诱导因子1(HIF-1)、原癌基因(c-Myc)等]、信号传导通路[酪氨酸激酶受体(MET)/磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)/雷帕霉素靶蛋白(mTOR)等],有效抑制细胞增殖、转移,降低肿瘤细胞耐药性以及调控细胞凋亡,从而实现治疗CRC、防止CRC复发和改善CRC预后的目标。尽管AEG在CRC的发生发展中扮演着重要角色,但其具体机制尚未完全阐明。因此,该文从肿瘤细胞糖酵解角度出发,深入分析AEG途径中关键作用靶点及作用机制与CRC之间的内在联系,探讨中药有效成分(如氧化苦参碱、山柰酚、薯蓣皂苷等)和复方(如祛邪胶囊、解毒三根汤、仙连解毒方等)通过干预AEG途径来治疗CRC。另外,该文还探讨了当前研究领域中存在的不足,以期为中医药治疗CRC提供可靠的治疗靶点和理论依据。Colorectal cancer(CRC)is a common malignant tumor worldwide.Due to the treatment intolerance and side effects,CRC rank the top among various cancers regarding the incidence and mortality rates.Therefore,exploring new therapies is of great significance for the treatment of CRC.Aerobic glycolysis(AEG)plays an important role in the microenvironment formation,proliferation,metastasis,and recurrence of CRC and other tumor cells.It has been confirmed that intervening in the AEG pathway can effectively curb CRC.The active ingredients and compound prescriptions of traditional Chinese medicine(TCM)can effectively inhibit the proliferation,metastasis,and drug resistance and regulate the apoptosis of tumor cells by modulating AEG-associated transport proteins[eg,glucose transporters(GLUT)],key enzymes[hexokinase(HK)and phosphofructokinase(PFK)],key genes[hypoxia-inducible factor 1(HIF-1)and oncogene(c-Myc)],and signaling pathways(MET/PI3K/Akt/mTOR).Accordingly,they can treat CRC,reduce the recurrence,and improve the prognosis of CRC.Although AEG plays a key role in the development and progression of CRC,the specific mechanisms are not yet fully understood.Therefore,this article delves into the intrinsic connection of the targets and mechanisms of the AEG pathway with CRC from the perspective of tumor cell glycolysis and explores how active ingredients(oxymatrine,kaempferol,and dioscin)and compound prescriptions(Quxie Capsules,Jiedu Sangen Decoction,and Xianlian Jiedu Prescription)of TCM treat CRC by intervening in the AEG pathway.Additionally,this article explores the shortcomings in the current research,aiming to provide reliable targets and a theoretical basis for treating CRC with TCM.

关 键 词：有氧糖酵解 结直肠癌 中药 综述 

分 类 号：R285[医药卫生—中药学]