木鳖子中4个新的双糖苷类成分  

Four new diglycosides from Momordicae Semen

作　　者：周成林 李晓波[1] 瀚培俊 丁如 王梦月[1] ZHOU Cheng-lin;LI Xiao-bo;JU Pei-jun;DING Ru;WANG Meng-yue(School of Pharmaceutical Science,Shanghai Jiao Tong University,Shanghai 200240,China;Shanghai Institute of Traditional Chinese Medicine for Mental Health,Shanghai 200030,China)

机构地区：[1]上海交通大学药学院,上海200240 [2]上海市中医神志病研究所,上海200030

出　　处：《中国中药杂志》2025年第6期1558-1563,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(82274061);内蒙古自治区“科技兴蒙”计划项目(2022XYJG0001-02-01);上海市中医神志病研究所开放课题(SZB2024206)。

摘　　要：木鳖子以种仁药用,但目前尚未见其种仁化学成分的研究报道。该研究采用硅胶柱色谱、半制备HPLC、HR-MS、NMR等技术,首次对木鳖子仁的化学成分进行研究,从中分离鉴定了8个成分,分别为对羟基苯甲酸-7-O-海藻糖苷(木鳖苷A,1)、2,6-二甲氧基苯酚-O-β-D-芹糖基-(1→2)-β-D-葡萄糖苷(木鳖苷B,2)、1-O-对甲氧基苯甲酰基-1,4-苯二酚-4-O-β-D-芹糖基-(1→2)-β-D-葡萄糖苷(木鳖苷C,3)、1-O-对羟基苯甲酰基-1,4-苯二酚-4-O-β-D-芹糖基-(1→2)-β-D-葡萄糖苷(木鳖苷D,4)、丝石竹皂苷元-3-O-β-D-半乳糖基-(1→2)-β-D-葡萄糖醛酸苷(5)、皂皮酸-3-O-β-D-半乳糖基-(1→2)-β-D-葡萄糖醛酸苷(6)、佛莱心苷(7)、山柰苷(8)。其中,化合物1~4为新化合物,化合物5~8为首次从木鳖子中分离得到。The seed kernel of Momordica cochinchinensis,i.e.,Momordicae Semen,is used for medicinal purposes,but to date,no research has been reported on its chemical constituents.In this study,the chemical constituents of Momordicae Semen were investigated for the first time using silica gel column chromatography,semi-preparative HPLC,HR-MS,and NMR.As a result,eight compounds were isolated and identified as:p-hydroxybenzoic acid-7-O-trehaloside(mubeside A,1),2,6-dimethoxyphenol-O-β-D-apiosyl-(1→2)-β-D-glucoside(mubeside B,2),1-O-p-methoxybenzoyl-1,4-benzenediol-4-O-β-D-apiosyl-(1→2)-β-D-glucoside(mubeside C,3),1-O-p-hydroxybenzoyl-1,4-benzenediol-4-O-β-D-apiosyl-(1→2)-β-D-glucoside(mubeside D,4),gypsogenin-3-O-β-D-galactosyl-(1→2)-β-D-glucuronoside(5),quillaic acid-3-O-β-D-galactosyl-(1→2)-β-D-glucuronoside(6),violanthin(7),and kaempferitrin(8).Compounds 1-4 are new compounds,while compounds 5-8 were isolated from Momordicae Semen for the first time.

关 键 词：木鳖子 种仁 双糖苷 木鳖苷 化学成分 

分 类 号：R284.1[医药卫生—中药学]