基于多元数据挖掘探讨中医药治疗高血压病左心室肥厚的方药规律  

Prescription pattern of traditional Chinese medicine for treatment of hypertensive left ventricular hypertrophy based on multivariate data mining

作　　者：王选阳 高原[1,2,3] 李彬 于瑞[1,3] 谢世阳[1,3] 周璐烨[1,2] 孙雨蝶 朱明军 WANG Xuan-yangv;GAO Yuan;LI Bin;YU Rui;XIE Shi-yang;ZHOU Lu-ye;SUN Yu-die;ZHU Ming-jun(Cardiac Center,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;the First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450000,China;Henan Engineering Research Center of Chinese Medicine Safety Evaluation and Risk Prevention and Control,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院心脏中心,河南郑州450000 [2]河南中医药大学第一临床医学院,河南郑州450000 [3]河南中医药大学第一附属医院河南省中药安全评价与风险防控工程研究中心,河南郑州450000

出　　处：《中国中药杂志》2025年第6期1688-1698,共11页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金青年科学基金项目(81503435);河南省中医药管理局国家中医临床研究基地科研专项(2018JDZX058);河南省中医药科学研究专项(2022ZY2009);河南省重点研发与推广专项(科技攻关)项目(242102310554,222301420086);横向课题(XZ2022013);华通国康医学科研专项(2023HT034)。

摘　　要：探讨中医药治疗高血压病左心室肥厚(left ventricular hypertrophy,LVH)的方药规律,为临床辨证论治提供相关理论依据。该文系统检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)数据库,筛选出中医药治疗高血压病LVH的文献,运用Microsoft Excel 2021建立相关处方数据库,对处方中所含中药进行频次、性味归经及功效分类的统计,通过Lantern 5.0与Rstudio软件对频率>3.50%的高频中药进行隐结构模型与关联规则分析,同时联合Origin 2024软件进行数据可视化展示等,以探讨中医药治疗高血压病LVH的方药规律。结果显示,共纳入中医药处方128个,涉及中药163味,累计频次1242次。高频中药有丹参、钩藤、天麻、茯苓与川芎等,功效以活血化瘀药、补虚药与平肝息风药为主。隐结构分析共获得10个隐变量、20个隐类、7个综合聚类模型,23个核心方剂,推测高血压病LVH常见证候有瘀血阻络证、肝阳上亢证、阴虚阳亢证与痰瘀互结证等。关联规则分析获得33条强关联规则,其中综合关联规则最高的是天麻→钩藤。高血压病LVH为本虚标实之证,以阴虚、气虚为本,“瘀”“痰”为标,临床治疗以活血化瘀、益气养阴为主,随证结合息风止痉、清热、祛湿化痰与利水消肿等治法。This study explored the prescription pattern of traditional Chinese medicine(TCM)in the treatment of hypertensive left ventricular hypertrophy(LVH),so as to provide a relevant theoretical basis for the clinical diagnosis and treatment of hypertensive LVH.The study systematically searched the databases of CNKI,Wanfang,VIP,and SinoMed to screen out the qualified literature on TCM treatment of hypertensive LVH and used Microsoft Excel 2021 to establish the relevant prescription database.It also counted the frequency,property,flavor,and meridian affiliation of TCM in the prescriptions and classified their efficacy.The study used Lantern 5.0 and Rstudio software to analyze the hidden structural models and association rules of the high-frequency TCM with a frequency of>3.50% and adopted Origin 2024 software to visualize the data,so as to explore the prescription pattern of TCM in treating hypertensive LVH.The results showed that a total of 128 TCM prescriptions were included,involving 163 TCM with a total frequency of 1242.The high-frequency TCM included Salviae Miltiorrhizae Radix et Rhizoma,Uncariae Ramulus Cum Uncis,Gastrodiae Rhizoma,Poria,and Chuanxiong Rhizoma,with the main efficacy from blood-activating and stasis-resolving herbs,tonic herbs,and liver-calming and wind-extinguishing herbs.The latent structure analysis(LSA)identified 10 latent variables,20 latent classes,7 comprehensive clustering models,and 23 core prescriptions.It was speculated that the common syndromes of hypertensive LVH included blood stasis obstructing the collaterals,ascending hyperactivity of liver Yang,Yin deficiency with Yang hyperactivity,and intermingled phlegm and blood stasis.The association rule analysis yielded 33 strong association rules,with the highest comprehensive association rule being Gastrodiae Rhizoma→Uncariae Ramulus Cum Uncis.Hypertensive LVH is characterized by asthenia in origin and asthenia in superficiality,with Yin deficiency and Qi deficiency as the origin and blood stasis and phlegm as the superficiality.Clinic

关 键 词：高血压病左心室肥厚 数据挖掘 中医药 方药规律 

分 类 号：R259[医药卫生—中西医结合]