清醒静息过程的记忆巩固:来自脑电和功能磁共振的证据  

Memory consolidation during wakeful rest:Evidence from EEG and fMRI

作　　者：雷旭 翁琳曼 喻婧 LEI Xu;WENG Linman;YU Jing(Faculty of Psychology,Southwest University,Sleep and Neuroimaging Center,Southwest University,Chongqing 400715,China)

机构地区：[1]西南大学心理学部,睡眠神经影像中心,重庆400715

出　　处：《心理科学进展》2025年第5期729-743,共15页Advances in Psychological Science

基　　金：国家自然科学基金面上项目(32471095)。

摘　　要：清醒静息和睡眠都有利于记忆离线巩固。但两者在记忆巩固中的联系和区别,特别是共有的认知神经机制我们仍知之甚少。本研究拟采用脑电、功能磁共振、时域干涉电刺激、计算神经科学建模等多项前沿技术,从三个方面开展工作:第一,通过清醒和睡眠的联合神经影像实验,对比记忆巩固在两种状态中的神经活动,揭示记忆离线巩固的本质特征;第二,搭建基于神经重放的闭环刺激系统,从因果关系出发探究记忆离线巩固的神经特征;第三,开展基于实时神经反馈的海马电刺激研究,开发针对记忆巩固调控的方案。本研究的开展,对阐明记忆离线巩固的神经机制具有重要的理论意义,也为未来清醒状态下记忆巩固的调控提供了科学依据。Both wakeful rest and sleep are beneficial for offline memory consolidation.However,our understanding of the connections and differences in memory consolidation between these two states,especially regarding the shared cognitive neural mechanisms,remains limited.This study adopts cutting-edge technologies,such as EEG,fMRI,temporal interference electrical stimulation,and computational neuroscience techniques,to carry out the following works.First,through joint neuroimaging experiments of waking rest and sleep,the neural activities of memory consolidation are compared between the two states to reveal the essential characteristics of offline memory consolidation.Second,establish a closed-loop stimulation system based on neural replay to investigate the neural characteristics of offline memory consolidation from a causal perspective.Third,conduct real-time neural feedback-based hippocampal electrical stimulation research to develop a protocol for regulating memory consolidation.This study holds profound theoretical significance for elucidating the neural mechanisms of offline memory consolidation and provides scientific evidence for the regulation of memory consolidation in the waking state in the future.

关 键 词：记忆巩固 陈述性记忆 程序性记忆 睡眠 静息态 

分 类 号：B845[哲学宗教—心理学]