芪龙益肾方对糖尿病肾脏疾病气阴两虚兼湿热血瘀证患者肾功能及氧化应激的影响  

Effect of Qilong Yishen Decoction on renal function and oxidative stress in patients with DKD qi and yin deficiency and damp heat and blood stasis syndrome

作　　者：黄艺 李桂霞 翟晓丽[1] 孙国华 邓再莉 戴泽亮[1] 黄磊[1] HUANG Yi;LI Guixia;ZHAI Xiaoli(Nephrology Department of the Second People’s Hospital of Lanzhou,Lanzhou 730046,China)

机构地区：[1]兰州市第二人民医院肾病科,兰州730046

出　　处：《中国处方药》2025年第7期96-100,共5页Journal of China Prescription Drug

基　　金：兰州市卫生健康行业科研项目(A2023029)。

摘　　要：目的通过观察芪龙益肾方对糖尿病肾脏疾病(DKD)气阴两虚兼湿热血瘀证患者肾功能、氧化应激指标的影响,评价其临床疗效。方法选取2022年9月~2023年10月就诊于兰州市第二人民医院符合纳入标准的DKD(Ⅲ~Ⅳ期)气阴两虚兼湿热血瘀证患者96例,将其随机分为对照组48例和治疗组48例。对照组给予西医基础治疗,治疗组给予西医基础治疗+芪龙益肾方。治疗8周后,分别检测治疗前后血清血肌酐(Scr)、尿素氮(BUN)、胱抑素-C(Cys-C)、肾小球滤过率(eGFR)、尿白蛋白/肌酐比值(UACR)、24 h尿蛋白定量(UTP)、超氧化物歧化酶(SOD)、同型半胱氨酸(Hcy)等指标的变化,进行统计分析,客观评价芪龙益肾方治疗DKDⅢ~Ⅳ期气阴两虚兼湿热血瘀证的临床疗效。结果治疗后,治疗组eGFR较治疗前升高,血Scr、Cys-C、BUN、UA较治疗前降低,差异有统计学意义(P<0.05),对照组血UA较治疗前降低,差异有统计学意义(P<0.05),而eGFR、血Scr、Cys-C、BUN比较差异无统计学意义(P>0.05)。治疗后,治疗组eGFR明显高于对照组,血Scr、Cys-C、BUN、UA明显低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者尿α1-MG、β2-MG、UACR、UTP较治疗前降低(P<0.05),且治疗组较对照组降低明显,差异有统计学意义(P<0.05)。治疗后两组患者血清Hcy、hs-CRP水平均较治疗前下降,SOD水平较治疗前升高(P<0.05);且治疗后治疗组Hcy、hs-CRP水平与对照组比较下降明显,SOD水平升高明显,差异有统计学意义(P<0.01)。两组治疗后中医证候积分均有下降(P<0.05);且治疗后治疗组中医症候积分明显低于对照组(P<0.05),中医证候疗效比较,治疗组总有效率(91.67%)优于对照组(77.08%),差异有统计学意义(P<0.05)。治疗组临床总有效率(85.42%)优于对照组(66.67%),差异有统计学意义(P<0.05)。结论芪龙益肾方可缓解DKD气阴两虚证兼湿热血瘀证患者的临床不适症状,具有改善肾功能指标、�Objective To observe the effect of Qilong Yishen Decoction on renal function and oxidative stress indexes in patients with DKD qi and yin deficiency and damp heat and blood stasis syndrome,the clinical efficacy was evaluated.Methods A total of 96 patients with DKD(stage III~IV)qi and yin deficiency syndrome and damp heat and blood stasis syndrome who met the criteria and hospitalized in the Department of Nephrology,the Second People's Hospital of Lanzhou from September 2022 to October 2023 were selected.These patients were randomly divided into the control group(48 cases)and the treatment group(48 cases).The control group was given basic treatment of western medicine,and the treatment group was given basic treatment of western medicine+Qilong Yishen Decoction.After 8 weeks of treatment,the changes of serum creatinine(Scr),urea nitrogen(BUN),cystatin-C(Cys-C),glomerular filtration rate(eGFR),urinary albumin/creatinine ratio(UACR),24-hour urinary protein quantification(UTP),superoxide dismutase(SOD),homocysteine(Hcy)and other indicators were detected before and after treatment.Statistical analysis was performed to objectively evaluate the clinical efficacy of Qilong Yishen Decoction in the treatment of DKD stageⅢ~Ⅳqi and yin deficiency and damp heat and blood stasis syndrome.Results After treatment,the eGFR of the treatment group was higher than that before treatment,and the blood Scr,Cys-C,BUN and UA were lower than those before treatment,the difference was statistically significant(P<0.05).The blood UA of the control group was lower than that before treatment,and the difference was statistically significant(P<0.05),while the eGFR,blood Scr,Cys-C and BUN were not statistically significant(P>0.05).Comparison between groups:After treatment,the eGFR of the treatment group was significantly higher than that of the control group,and the blood Scr,Cys-C,BUN and UA were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the urineβ1-MG,β2-MG,U

关 键 词：糖尿病肾脏疾病 芪龙益肾方 氧化应激 

分 类 号：R259[医药卫生—中西医结合]