基于德尔菲法分析精子DNA损伤性不育的中医病名、相关脏腑及基本证型  

TCM Disease Name,Related Zang and Fu as Well as Basic Syndrome of Sperm DNA Damage Induced Infertility Based on Delphi Method

作　　者：马苗苗 琚保军[1] 张琦[1] 陈如兵 王祖龙[1] MA Miaomiao;JU Baojun;ZHANG Qi;CHEN Rubing;WANG Zulong(Department of Andrology,The First Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450000;The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou Henan China 450000)

机构地区：[1]河南中医药大学第一附属医院男科,河南郑州450000 [2]河南中医药大学第一临床医学院,河南郑州450000

出　　处：《中医学报》2025年第5期924-929,共6页Acta Chinese Medicine

基　　金：国家自然科学基金面上项目(82174377)。

摘　　要：目的:通过德尔菲法分析精子DNA损伤性不育的中医病名、相关脏腑及证候分布。方法:查阅文献及书籍,制定DNA损伤性不育的中医病名、相关脏腑及证候分布问卷。邀请本领域权威专家进行问卷咨询,并对问卷数据进行汇总整理,计算专家积极系数、集中程度、协调程度、专家权威程度及问卷信度,至专家意见基本达到一致。结果:专家积极系数为94.29%(第一轮)、97.56%(第二轮),工作年限集中在20年以上,来自北京、上海等16个省/直辖市;问卷肯德尔和谐系数(Kendall′s W)为0.81(P<0.001);精子DNA损伤性不育中医病名、相关脏腑、中医证型的专家权威系数Q分别是0.81、0.81、0.83,整体问卷的格朗巴赫α系数为0.834,专家推荐程度、协调程度、专家权威系数、问卷信度均较高,专家基本形成一致意见,结果较为可靠。结论:推荐“不育”作为精子DNA损伤性不育的中医病名,认为肾、脾与本病关系最为密切,肾精亏虚证、湿热瘀滞证、肾虚血瘀证、脾肾两虚证、脉络瘀阻证为本病基本证型。Objective:To analyze the Chinese medicine disease name,related Zang and Fu as well as the basic evidence patterns of sperm DNA damage infertility based on Delphi method.Methods:Literature and books were consulted to develop a questionnaire on the TCM disease names,related Zang and Fu as well as basic syndrome patterns of DNA damage infertility.Authoritative experts in this field were invited to consult the questionnaire,and the questionnaire data were summarized and organized to calculate the positive coefficient of the experts,the degree of concentration,the degree of coordination,the degree of authority of the experts and the degree of reliability of the questionnaire,until the opinions of the experts basically reached the same.Results:the positive coefficient of experts was 94.29%(the first round)and 97.56%(the second round),and their working years were concentrated in more than 20 years,from 16 provinces/municipalities directly under the central government,such as Beijing,Shanghai,etc.;the questionnaire Kendall′s W coefficient of harmony(Kendal′s W)was 0.81(P<0.001);the names of Chinese medicine disease in spermatozoa DNA damage infertility,related expert authority coefficients Q of sperm DNA damage infertility in TCM disease name,related Zang and Fu,and TCM syndrome type were 0.81,0.81,0.83,respectively,and the overall questionnaire′s Gronbach′s alpha coefficient was 0.834.The degree of expert recommendation,degree of harmonization,expert authority coefficient,and questionnaire′s reliability were all high,and the experts basically formed a unanimous opinion,and the result was more reliable.Conclusion:We recommend"infertility(不育)"as the name of sperm DNA damage infertility in Chinese medicine and it is believed that the Kidney and Spleen have the closest relationship with this disease,and that Kidney Essence deficiency syndrome,Dampness-Heat stagnation syndrome,Kidney deficiency and blood stasis syndrome,deficiency of the Spleen and Kidney syndrome as well as stasis in collaterals syndrome are t

关 键 词：精子DNA损伤 男性不育 德尔菲法 中医证型 中医病名 

分 类 号：R277.598.2[医药卫生—中医学]