基于“生气邪气皆本于阴阳”探析当归饮子辨治肺癌靶向治疗后皮疹  

Danggui Drink Treating Target Drug Induced Skin Rash of Lung Cancer Based on"Both Physiological Qi and Evil Factor Qi Rooting in Yin and Yang"

作　　者：马苏苏 李经蕾 杜炎远 蔡柳 李柏慧 郑红刚[1,2,3] MA Susu;LI Jinglei;DU Yanyuan;CAI Liu;LI Baihui;ZHENG Honggang(Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing China 100053;Beijing University of Chinese Medicine,Beijing China 100029;Shaanxi University of Chinese Medicine,Xi′an Shaanxi China 712046)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学,北京100029 [3]陕西中医药大学,陕西西安712046

出　　处：《中医学报》2025年第5期950-954,共5页Acta Chinese Medicine

基　　金：国家自然科学基金面上项目(82174463);中央高水平中医医院临床研究和成果转化能力提升项目-传承名老中医药专家学术经验专项项目(HLCMHPP2023007)。

摘　　要：目前,肺癌在我国是发病率和病死率最高的恶性肿瘤,靶向药是抑制肺癌进展的重要治疗手段,但皮疹等不良反应常给用药患者带来痛苦。邪气本于阴阳,风为阳邪,靶向药治疗后患者易感受风邪,与其自身阴阳失衡密不可分。靶向药所致皮疹为正虚受外风、血虚生内风,又因辛热药毒引发所致。当归饮子以养血祛风为要,可滋阴养血以复“生气”、熄风调气以祛“邪气”、益气化血兼顾阴阳转化,蕴含阴阳制衡的勃勃生机,与肺癌靶向治疗后皮疹的病机相合。临床应用当归饮子辨治肺癌靶向治疗后皮疹常获佳效。Lung cancer is the malignant tumor with the highest morbidity and mortality rate in China.Target medicine is an important therapeutic means to inhibit the progression of lung cancer,but adverse reactions such as skin rash often bring pain to patients who use the medicine.Evil factor Qi rooting in Yin and Yang,and Wind is a kind of Yang evil factor.Patients are prone to suffer from the Wind evil factor after target drug therapy,which is inextricably linked to the imbalance of Yin and Yang in themselves.The pathomechanism of rash induced by target drug is external Wind injury when there is Zheng Qi deficiency and internal Wind injury when there is blood deficiency as well as the outcome of the toxicity of pungent and hot drugs.Danggui Drink functions in nourishing blood and eliminating Wind,which can nourish Yin and produce blood to restore"the physiological Qi",can stop the Wind and can regulate Qi to get rid of"the evil factor Qi",and can benefit Qi and blood to help with the transformation between Yin and Yang.The prescription contains the vitality of Yin and Yang balance,which is compatible with the pathogenesis of target drug induced skin rash of lung cancer.Clinical application of Danggui Drink in treating target drug induced skin rash of lung cancer is quite effective in most cases.

关 键 词：肺癌 皮疹 靶向治疗 当归饮子 “生气本于阴阳” “邪气本于阴阳” 滋阴养血 熄风调气 益气生血 

分 类 号：R273[医药卫生—中西医结合]