中医药影响芳香烃受体介导慢性肾脏病肾纤维化  

Traditional Chinese Medicine Influencing Aromatic Hydrocarbon Receptor-Mediated Renal Fibrosis in Chronic Kidney Disease

作　　者：田力臻 王雨典 张薇 王娟[1] 胡安澜 于小勇 TIAN Lizhen;WANG Yudian;ZHANG Wei;WANG Juan;HU Anlan;YU Xiaoyong(Shaanxi University of Chinese Medicine,Xianyang Shaanxi China 712046;Shaanxi Provincial Hospital of Traditional Chinese Medicine,Xi′an Shaanxi China 710003)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西省中医医院,陕西西安710003

出　　处：《中医学报》2025年第5期1032-1038,共7页Acta Chinese Medicine

基　　金：国家自然科学基金项目(82174366)。

摘　　要：肾纤维化是全球性的健康问题,也是各种慢性肾脏病进展至终末期肾病的主要病理结果,多种信号通路调控肾纤维化的进程,迄今为止仍缺乏有效抑制甚至逆转其进展的方法。芳香烃受体(aryl hydrocarbon receptor,AhR)是一种配体激活的转录因子,可介导多种内源性物质代谢产物和外源毒性物质的毒理效应。研究表明,AhR在许多类型的细胞中广泛表达,并参与多种生物过程,在肾脏纤维化中起着重要作用。中医药能通过调节AhR信号通路抑制慢性肾脏病肾组织损伤,改善肾纤维化进展与疾病预后,提升患者生活水平。Renal fibrosis is a global health problem and a major pathological outcome of various chronic kidney diseases progressing to end-stage renal disease.Multiple signaling pathways regulate the progression of renal fibrosis,and so far there is still a lack of effective methods to inhibit or even reverse its progression.The aryl hydrocarbon receptor(AhR)is a ligand-activated transcription factor that mediates the toxicological effects of a variety of endogenous substance metabolites and exogenous toxicants.Studies have shown that AhR is widely expressed in many types of cells and is involved in a variety of biological processes,playing an important role in renal fibrosis.Traditional Chinese medicine can inhibit renal tissue injury in chronic kidney disease by regulating the AhR signaling pathway,improve the progression of renal fibrosis and disease prognosis,and enhance patients′living standards.

关 键 词：芳香烃受体 慢性肾脏病 肾纤维化 

分 类 号：R256.59[医药卫生—中医内科学]