毛德西论治围绝经期失眠的用药规律  

Mao Dexi′s Medication Rule in Treatment of Perimenopausal Insomnia

作　　者：张欣瑜 牛琳琳[1] 冯玮 薛蕊蕊 毛德西[3] ZHANG Xinyu;NIU Linlin;FENG Wei;XUE Ruirui;MAO Dexi(Heart Center of the First Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450000;The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou Henan China 450000;The Second Affiliated Hospital to Henan University of Chinese Medicine/Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou Henan China 450000)

机构地区：[1]河南中医药大学第一附属医院心脏中心,河南郑州450000 [2]河南中医药大学第一临床医学院,河南郑州450000 [3]河南中医药大学第二附属医院/河南省中医院,河南郑州450002

出　　处：《中医学报》2025年第5期1075-1079,共5页Acta Chinese Medicine

基　　金：全国名中医传承工作室建设项目{国中医药办人教函〔2018〕119号};第六批全国老中医药专家学术经验继承项目{国中医药人教发〔2017〕29号};河南省中医学“双一流”创建科学研究专项资助项目(HSRP-DFCTCM-2023-1-34)。

摘　　要：目的:通过数据挖掘探析毛德西教授治疗围绝经期失眠的用药规律。方法:搜集毛德西教授2018-2023年治疗围绝经期失眠的处方,运用中医传承辅助系统V3.50对使用药物的频次、性味、归经、功效等进行统计及核心处方研究,分析处方用药的基本特点。结果:对筛选所得140首处方进行分析,涉及170味中药,得出高频药物17味,药性以平、寒、温为主,药味以甘、苦、辛为主,归经以心、肝、脾为主,药物功效以补虚、安神、清热、活血为主。对处方用药进行关联规则分析,得到常用药物组合为甘草-酸枣仁,酸枣仁-合欢皮,甘草-川芎,柏子仁-甘草,甘草-茯神等。基于K-means算法进行聚类分析,进一步演化出3组核心处方,分别以酸枣仁汤合交泰丸、疏调汤、柴胡加龙骨牡蛎汤为基础方。结论:毛德西教授治疗围绝经期失眠主要从心、肝、脾三脏论治,用药平和,治疗以养阴清热、调畅气机、重镇安神为主。Objective:To explore the medication rule of Prof.Mao Desi in treating perimenopausal insomnia through data mining.Methods:The prescriptions of Professor Mao Desi for the treatment of perimenopausal insomnia from 2018 to 2023 were collected,and the frequency,nature and flavor,meridian tropism,and efficacy of the medicines used were studied statistically and core prescription research was conducted by using the Traditional Chinese Medicine Transmission Aid System V3.50 to analyze the basic characteristics of the medications used in the prescriptions.Results:The 140 prescriptions obtained from the screening were analyzed,involving 170 flavors of Chinese medicines,resulting in 17 high-frequency medicines,with the properties being Neutral,Cold and Warm and the tastes being sweet,bitter and pungent,the meridian tropism being Heart,Liver and Spleen,and the efficacies of the medicines being tonifying deficiency,tranquilizing mind,clearing Heat and activating blood circulation.The association rules were analyzed for the prescription drugs,and the commonly used drug combinations were Gancao-Suanzaoren(Licorice-Spina date seed),Suanzaoren-Hehuanpi(Spina date seed-Cortex albiziae),Gancao-Chuanxiong(Licorice-Ligusticum wallichii),Baiziren-Gancao(Semen platyclade-Licorice),Gancao-Fushen(Licorice-Poria cum Ligno Hospite),etc.The combination of the drugs was analyzed based on K-means algorithm.Cluster analysis based on the k-means algorithm further evolved three groups of core prescriptions,which were based on Suanzaoren Decoction combined with Jiaotai Pill,Shutiao Decoction as well as Chaihu plus Longgu Muli Decoction,respectively.Conclusion:Prof.Mao Dexi′s treatment of perimenopausal insomnia was mainly based on the treatment of the Heart,Liver and Spleen,with the mild drugs,and the treatment was based on nourishing Yin and clearing Heat,regulating Qi,and tranquilizing the mind with heavy mineral drugs.

关 键 词：围绝经期失眠 数据挖掘 用药规律 毛德西 

分 类 号：R256.23[医药卫生—中医内科学]