从肠道菌群紊乱视角探讨疏肝和胃防治抑郁症的思路  

Ideas of Liver-soothing and Stomach-harmonizing Therapy to Prevent and Treat Depression from the Perspective of Gut Microbiota Dysbiosis

作　　者：张凌威 郑入文[2] 图娅[1,3] 王瑜 陈璐 姜会梨 ZHANG Lingwei;ZHENG Ruwen;TU Ya;WANG Yu;CHEN Lu;JIANG Huili(School of Acupuncture-Moxibustion and Tuina,Beijing University of Chinese Medicine,Beijing 100029,China;Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China;International Research Center for Mental Disorders,Beijing University of Chinese Medicine,Beijing 100029,China;Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学针灸推拿学院,北京100029 [2]北京中医药大学东方医院,北京100078 [3]北京中医药大学国际精神疾患研究中心,北京100029 [4]中国中医科学院针灸研究所,北京100700 [5]北京中医药大学中医学院,北京100029

出　　处：《世界中医药》2025年第3期491-495,共5页World Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(81904313)——针刺对抑郁症小胶质细胞M1/M2型极化紊乱诱导神经炎症的调控机制研究;国家自然科学基金面上项目(81973937)——“治病求本”:针刺干预抑郁/焦虑“共病”上游关键效应机制研究。

摘　　要：抑郁症是当代重大精神疾患,肝胃不和是其重要的中医病机。近年来研究发现,肠道菌群紊乱与抑郁症发病具有一定相关性,而中医“肝”和“胃”功能与肠道菌群的功能特性具有许多共通之处。研究表明,肝胃不和的本质可能与肠道菌群紊乱有关,临床多采用疏肝和胃法不仅能有效改善焦虑抑郁的症状,缓解精神障碍,还可调节肠道菌群功能。本文拟从肠道菌群紊乱的角度,探讨疏肝和胃法论治抑郁症的作用机制,以期为抑郁症的临床防治提供新的思路和证据。Depression is a major contemporary psychiatric disorder,with liver-stomach disharmony being an important pathogenesis in traditional Chinese medicine(TCM).Recent studies have found a certain correlation between gut microbiota dysbiosis and the onset of depression,and there are many commonalities between the functional characteristics of the TCM concepts of the“liver”and“stomach”and those of the gut microbiota.Research suggests that the essence of liver-stomach disharmony may be related to gut microbiota dysbiosis.Clinically,the liver-soothing and stomach-harmonizing therapy is widely used,not only effectively alleviating anxiety and depressive symptoms and mitigating mental disorders but also regulating gut microbiota function.This paper aims to explore the mechanism of the liver-soothing and stomach-harmonizing therapy in the treatment of depression from the perspective of gut microbiota dysbiosis,providing new insights and evidence for the clinical prevention and treatment of depression.

关 键 词：抑郁症 肝胃不和 肠道菌群 疏肝和胃 下丘脑-垂体-肾上腺轴 单胺类神经递质 细胞因子 脑源性神经营养因子 

分 类 号：R246.6[医药卫生—针灸推拿学]