某院2092份药品不良反应报告回顾性分析  

A Retrospective Analysis of 2 092 Adverse Drug Reaction Reports in a Hospital

作　　者：钟科[1] 黄春红 陈瑶 范小村 杨勇[2,3] ZHONG Ke;HUANG Chunhong;CHEN Yao;FAN Xiaocun;YANG Yong(Linshui County People's Hospital,Guang'an,Sichuan,China 638500;Sichuan Academy of Medical Sciences·Affiliated Hospital of UESTC·Sichuan Provincial People's Hospital,Chengdu,Sichuan,China 610072;Personalized Drug Therapy Key Laboratory of Sichuan Province,School of Medicine,UESTC,Chengdu,Sichuan,China 610072)

机构地区：[1]四川省广安市邻水县人民医院,四川广安638500 [2]四川省医学科学院·电子科技大学附属医院·四川省人民医院,四川成都610072 [3]电子科技大学医学院个体化药物治疗四川省重点实验室,四川成都610072

出　　处：《中国药业》2025年第9期30-34,共5页China Pharmaceuticals

基　　金：国家卫生健康委员会医院管理研究所医院药学高质量发展研究项目[NIHAYS2323]。

摘　　要：目的分析某院药品不良反应(ADR)的发生特点,为合理用药提供参考。方法回顾性分析四川省广安市邻水县人民医院2014年1月至2023年12月在国家ADR监测系统上报的2092份ADR报告,根据患者的性别、年龄、涉及药品种类、给药途径、累及系统/器官、ADR严重程度分级、转归等进行统计与分析。结果2092份ADR报告涉及患者2092例,其中,男1052例(50.29%),女1040例(49.71%);≤18岁的287例(13.72%),≥65岁患者的ADR发生率较高(35.76%);涉及药品类别中,全身用抗感染药物540例(25.81%),血液和造血系统药物341例(16.30%),中药成方212例(10.13%);给药途径主要为静脉滴注(68.59%)和口服(22.80%);主要累及皮肤及其附件(38.34%)和消化系统(29.11%);新的ADR 471例(22.51%),严重ADR 187例(8.94%);转归为良好的2076例(99.24%),未见好转、不详、有后遗症的分别有3例、12例、1例。结论该院需加强ADR监测和ADR相关知识宣传力度,以降低ADR发生率,提高ADR上报质量,促进药物的合理使用。Objective To analyze the characteristics of adverse drug reactions(ADRs)in a hospital,and to provide a reference for rational drug use.Methods A retrospective analysis was conducted on 2092 ADR reports in the national ADR monitoring system reported by the Linshui County People's Hospital from January 2014 to December 2023.Statistical analysis was conducted on the patients'gender,age,types of drugs involved,administration routes,involved systems/organs,severity grading of ADRs,and outcomes.Results Among 2092 ADR reports,2092 patients were involved,including 1052 males(50.29%)and 1040 females(49.71%);287 cases(13.72%)were≤18 years old,and the incidence of ADR was higher in patients aged≥65(35.76%).Among the types of drugs involved,540 cases(25.81%)were treated with systemic anti-infective drugs,341 cases(16.30%)were treated with blood and hematopoietic system drugs,and 212 cases(10.13%)were treated with traditional Chinese medicine prescriptions.The main administration routes were intravenous infusion(68.59%)and oral administration(22.80%).ADRs mainly involved the skin and its appendages(38.34%)and digestive system(29.11%).There were 471 new ADRs(22.51%)and 187 severe ADRs(8.94%).A total of 2076 cases(99.24%)had a good outcome,while three cases showed no improvement,twelve cases were unknown,and one case had sequelae.Conclusion The hospital needs to strengthen ADR monitoring and promote ADR-related knowledge to reduce the incidence of ADR,improve the quality of ADR reporting,and promote rational drug use.

关 键 词：国家药品不良反应监测系统 药品不良反应 常见不良事件评价标准 回顾性分析 

分 类 号：R95[医药卫生—药学]