健脾利湿解毒方联合抗人乳头瘤病毒蛋白辅料治疗宫颈锥切术后持续感染人乳头瘤病毒临床观察  

Clinical Observation of Jianpi Lishi Jiedu Formula Combined with Anti-HPV Protein Excipients in the Treatment of Patients with Persistent HPV Infection After Cervical Conectomy

作　　者：倪雅丽 颛佳 赵云彦 孙佳 陈瑞雪 邵迎华 杨秀梅 NI Yali;ZHUAN Jia;ZHAO Yunyan;SUN Jia;CHEN Ruixue;SHAO Yinghua;YANG Xiumei(Cangzhou People's Hospital,Cangzhou,Hebei,China 061000)

机构地区：[1]河北省沧州市人民医院,河北沧州061000

出　　处：《中国药业》2025年第9期97-100,共4页China Pharmaceuticals

基　　金：河北省中医药管理局科研计划项目[2023456]。

摘　　要：目的探讨健脾利湿解毒方联合抗人乳头瘤病毒(HPV)蛋白辅料治疗宫颈锥切术后持续感染HPV患者的临床疗效。方法选取医院2022年6月至2023年6月收治的宫颈锥切术后持续感染HPV患者96例,按随机数字表法分为对照组和观察组,各48例。两组患者均予抗HPV蛋白辅料治疗,观察组患者加用健脾利湿解毒方内服,两组患者均以30 d为1个疗程,经期停药,连续治疗3个疗程。结果观察组的总有效率为91.67%,显著高于对照组的72.92%(P<0.05)。治疗后,两组患者的中医证候(赤白带下、月经淋漓、腰酸腹痛、舌红苔黄)积分及炎性因子(血清淀粉样蛋白A、粒细胞集落刺激因子、白细胞介素33)、免疫功能指标[辅助型T细胞2(Th2)]水平均显著降低(P<0.05),且观察组均显著低于对照组(P<0.05);两组患者的辅助型T细胞1(Th1)水平、Th1/Th2均显著升高(P<0.05),且观察组均显著高于对照组(P<0.05)。治疗期间,观察组和对照组不良反应发生率相当(12.50%比8.33%,P>0.05)。结论健脾利湿解毒方联合抗HPV蛋白辅料治疗宫颈锥切术后持续感染HPV的临床疗效良好,可减轻患者的中医证候,降低炎性因子水平,提升免疫功能,且安全性良好。Objective To investigate the clinical efficacy of the Jianpi Lishi Jiedu Formula combined with anti-human papillomavirus(HPV)protein excipients in the treatment of patients with persistent HPV infection after cervical conectomy.Methods A total of 96 patients with persistent HPV infection after cervical conectomy admitted to the hospital from June 2022 to June 2023 were selected and randomly divided into the control group and the observation group by the random number table method,with 48 cases in each group.The patients in the two groups were treated with anti-HPV protein excipients,while the patients in the observation group were given an oral administration of Jianpi Lishi Jiedu Formula.Both groups were treated for three consecutive courses of treatment with 30 d as a course of treatment(drug withdrawal during menstruation).Results The total effective rate in the observation group was 91.67%,which was significantly higher than 72.92%in the control group(P<0.05).After treatment,the traditional Chinese medicine(TCM)syndrome(vaginal discharge,menostaxis,lumbosacral pain,tongue redness and yellow coating)scores,inflammatory factors(serum amyloid A,granulocyte colony-stimulating factor,interleukin-33)levels,and immune function index[helper T cell 2(Th2)]level in the two groups significantly decreased(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05);the levels of helper T cell 1(Th1)level and Th1/Th2 in the two groups significantly increased(P<0.05),and those in the observation group were significantly higher than those in the control group(P<0.05).During the treatment period,the incidence of adverse reactions was comparable between the observation group and the control group(12.50%vs.8.33%,P>0.05).Conclusion Jianpi Lishi Jiedu Formula combined with anti-HPV protein excipients has good efficacy and safety in the treatment of patients with persistent HPV infection after cervical conectomy,which can alleviate patients'TCM syndromes,reduce inflammatory factor le

关 键 词：抗人乳头瘤病毒蛋白辅料 健脾利湿解毒方 人乳头瘤病毒 宫颈锥切术后 中医证候 炎性因子 免疫功能 临床疗效 

分 类 号：R932[医药卫生—生药学] R285.6[医药卫生—药学]