全息刮痧联合大承气汤加减保留灌肠治疗恶性肠梗阻临床研究  

Clinical Study of Holographic Scraping Combined with Modified Dachengqi Decoction Retention Enema in the Treatment of Malignant Intestinal Obstruction

作　　者：于子晨 张丽曼 刘翠 于瑞雪 YU Zichen;ZHANG Liman;LIU Cui;YU Ruixue(Hengshui Hospital of Traditional Chinese Medicine,Hengshui,Hebei,China 053000;Hengshui Open University,Hengshui,Hebei,China 053000)

机构地区：[1]河北省衡水市中医医院,河北衡水053000 [2]衡水开放大学,河北衡水053000

出　　处：《中国药业》2025年第9期105-108,共4页China Pharmaceuticals

基　　金：河北省中医药管理局中医药类科研计划项目[2021362]。

摘　　要：目的探讨全息刮痧联合大承气汤加减保留灌肠治疗恶性肠梗阻(MBO)的临床疗效,以及对患者胃肠道功能与血清肠三叶因子3(ITF3)、高迁移率族蛋白B1(HMGB1)水平的影响。方法选取医院2021年2月至2023年12月收治的MBO患者156例,按随机数字表法分为联合组和对照组,各78例。对照组患者予大承气汤加减保留灌肠,联合组患者在对照组治疗基础上予全息刮痧。两组患者均以7 d为1个疗程,共连续治疗2个疗程。结果联合组总有效率为91.03%,显著高于对照组的78.21%(P<0.05);治疗后,联合组患者的胃肠道功能恢复时间、住院时间及血清HMGB1水平均显著低于对照组(P<0.05),各项肠梗阻症状评分、KPS评分及血清ITF3水平均显著高于对照组(P<0.05)。两组患者治疗期间均未发生明显不良反应。结论全息刮痧联合大承气汤加减保留灌肠治疗MBO的临床疗效良好,能改善患者的胃肠道功能和血清ITF3与HMGB1水平,提高患者的生活质量,且治疗安全性较好。Objective To investigate the clinical efficacy of holographic scraping combined with modified Dachengqi Decoction retention enema in the treatment of malignant intestinal obstruction(MBO),and its effect on gastrointestinal function and serum levels of intestinal trefoil factor 3(ITF3)and high mobility group protein B1(HMGB1).Methods A total of 156 patients with MBO admitted to the hospital from February 2021 to December 2023 were randomly divided into the combination group and the control group by the random number table method,with 78 cases in each group.The patients in the control group were given modified Dachengqi Decoction retention enema,on this basis,the patients in the combination group patients were given holographic scraping therapy.Both groups were treated for two consecutive courses of treatment with 7 d as one course of treatment.Results The total effective rate in the combination group was 91.03%,which was significantly higher than 78.21%in the control group(P<0.05).After treatment,the recovery time of various gastrointestinal functions,length of hospital stay,and serum HMGB1 level in the combination group were significantly lower than those in the control group(P<0.05),the scores of various intestinal obstruction symptoms,KPS score,and serum ITF3 level in the combination group were significantly higher than those in the control group(P<0.05).No significant adverse reactions observed in the two groups during the treatment period.Conclusion Holographic scraping combined with modified Dachengqi Decoction retention enema has good clinical efficacy and safety in the treatment of MBO,which can improve the patients'gastrointestinal function,serum ITF3 and HMGB1 levels,and quality of life.

关 键 词：全息刮痧 大承气汤加减保留灌肠 恶性肠梗阻 胃肠道功能 肠三叶因子3 高迁移率族蛋白B1 临床疗效 

分 类 号：R932[医药卫生—生药学] R285.6[医药卫生—药学]