急性冠脉综合征患者PCI术后应用小剂量替格瑞洛的疗效  

Efficacy analysis of low dose ticagrelor in patients with ACS after PCI

作　　者：杨民从 孙俊华[1] 李风祥 Yang mincong;Sun junhua;Li fengxiang(Zhengzhou Seventh People's Hospital,Zhengzhou,450000,China)

机构地区：[1]郑州市第七人民医院,450000

出　　处：《临床心电学杂志》2025年第1期23-26,31,共5页Journal of Clinical Electrocardiology

摘　　要：目的探究急性冠脉综合征(Acute coronary syndrome,ACS)行经皮冠状动脉介入术(PCI)术后患者维持服用小剂量替格瑞洛的疗效。方法纳入2021年4月至2023年4月期间121例急性冠脉综合征行PCI术后患者作为研究对象,以随机数字表法分为两组,其中对照组60例术后给予氯吡格雷,观察组61例给予替格瑞洛,对比治疗6月后两组患者的临床疗效、血小板功能、心率变异性、心肺适能及不良反应。结果观察组RR平均间期标准差(SDNN)、短时程平均RR间期标准差(SDANN)、高频功率(HF)水平高于对照组,低频功率(LF)高于对照组(P<0.05);每分钟通气量/二氧化碳排出量(VE/VCO_(2))、无氧域耗氧量(VO_(2))高于对照组(P<0.05);不良反应率低于对照组(P<0.05)。结论小剂量替格瑞洛应用于PCI的术后患者在抑制血小板聚集,恢复心脏功能和心肺能力方面疗效更佳,减少不良反应。Objective To investigate the efficacy of maintaining low doses of ticagrelor in patients with acute coronary syndromes(acute coronary syndrome,ACS)after percutaneous coronary intervention(PCI).Methods A total of121 patients with acute coronary syndrome who underwent PCI from April 2021 to April 2023 were included as study subjects and divided into two groups by random number table method.60 patients in the control group were given clopidogrel and 61 patients in the observation group were given ticagrelor Clinical efficacy,platelet function,heart rate variability,cardiopulmonary fitness and adverse reactions in two groups after a month.Results the standard deviation of NN intervals(SDNN)and the Standard Deviation of the Average RR interval(SDNN)in the observation group were respectively Normal-to-Normal Interval(SDANN),High frequency power(HF)and Low frequency power(LF)were higher than control group(P<0.05).The ventilate/carbon dioxide output per minute(VE/VCO_(2))and oxygen consumption(VO_(2))in anaerobic domain were higher than those in control group(P<0.05).The adverse reaction rate was lower than that of control group(P<0.05).Conclusions Low dose ticagrelor is more effective in inhibiting platelet aggregation,restoring cardiac function and cardiopulmonary capacity in patients after PCI,and reducing adverse reactions.

关 键 词：急性冠脉综合征 氯吡格雷 替格瑞洛 血小板功能 心率变异性 

分 类 号：R541.7[医药卫生—心血管疾病] R540.41[医药卫生—内科学]