奥美沙坦酯联合尼群地平对高血压患者血压变异性的影响  

Effect of Olmesartan cilexetil combined with Nitrendipine on blood pressure variability and oxidative stress in patients with essential hypertension

作　　者：武培 王志文 Wu pei;Wang zhiwen(Department of Internal Medicine,Zhoukou Women's and Children's Hospital,Zhoukou,Henan,466000,China)

机构地区：[1]周口市妇幼保健院(周口市儿童医院),466000

出　　处：《临床心电学杂志》2025年第1期27-31,共5页Journal of Clinical Electrocardiology

摘　　要：目的探究奥美沙坦酯联合尼群地平对原发性高血压患者血压变异性及机体氧化应激反应的影响。方法选取2022年1月至2023年8月于本院就诊的原发性高血压患者100例,根据治疗方案不同分为对照组(n=50)、观察组(n=50)。对照组给予尼群地平治疗,观察组于对照组基础上予以奥美沙坦酯治疗。比较两组临床疗效、治疗前后血压变异性[24h SBP标准差(24h SSD)、白昼SBP标准差(dSSD)、白昼DBP标准差(d DSD)、24h DBP标准差(24h DSD)、夜间SBP标准差(nSSD)、夜间DBP标准差(nDSD)]、氧化应激[丙二醛(MDA)、超氧化物歧化酶(SOD)]、相关血清因子[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、基质金属蛋白酶-9(MMP-9)]水平及不良反应发生率。结果观察组临床总有效率94.00%高于对照组78.00%(P<0.05);治疗后观察组dSSD、24h DSD、nDSD、24h SSD、nSSD、dDSD水平低于对照组(P<0.05);治疗后观察组血清MDA水平低于对照组,SOD水平高于对照组(P<0.05);治疗后观察组血清IL-6、TNF-α、hs-CRP、MMP-9水平低于对照组(P<0.05);观察组不良反应发生率12.00%与对照组6%相比,无统计学差异(P>0.05)。结论奥美沙坦酯联合尼群地平治疗原发性高血压疗效显著,不仅可调节血压变异性,改善机体氧化应激反应,还可抑制炎性反应,且具有一定安全性。Objective To explore the effect of Olmesartan Cilexetil combined with Nitrendipine on blood pressure variability and oxidative stress in patients with essential hypertension.Methods A total of 100 cases of EH patients in our hospital from January 2022 to August 2023 were selected and divided into control group(n=50)and observation group(n=50)according to different treatment schemes.The control group was treated with nitrendipine,and the observation group was treated with Olmesartan Cilexetil on the basis of the control group.The clinical efficacy of the two groups were compared,as well as the levels of blood pressure variability[24h SBP standard deviation(24h SSD),daytime SBP standard deviation(dSSD),daytime DBP standard deviation(dDSD),24h DBP standard deviation(24h DSD),nighttime SBP standard deviation(nSSD),nighttime DBP standard deviation(nDSD)],oxidative stress[malondialdehyde(MDA),superoxide dismutase(SOD)],related serum factors[tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),Matrix metallo proteinase-9(MMP-9)]before and after treatment,and the incidence of adverse reactions was also compared between the two groups.Results The total effective rate of the observation group was 94.00%,which was higher than 78.00%of the control group(P<0.05);after treatment,the levels of dSSD,24h DSD,nDSD,24h SSD,nSSD and dDSD in the observation group were lower than those in the control group(P<0.05);after treatment,the serum MDA level of the observation group was lower than that of the control group,and the SOD level was higher than that of the control group(P<0.05);after treatment,serum levels of IL-6,TNF-α,hs-CRP and MMP-9 in the observation group were lower than those in the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the observation group(12.00%)and the control group(6%)(P>0.05).Conclusions Olmesartan cilexetil combined with nitrendipine is effective in the treatment of EH,which can not only regulate blood pressu

关 键 词：奥美沙坦酯 尼群地平 原发性高血压 血压变异性 氧化应激 

分 类 号：R541.7[医药卫生—心血管疾病] R540.41[医药卫生—内科学]