前列腺液卵磷脂小体、炎症因子及免疫球蛋白与慢性前列腺炎的相关性分析  

Correlation of small patticle of lecithin,inflammatory factors,and immunoglobulins in prostatic fluid with chronic prostatitis

作　　者：李春晖[1] Li Chunhui(Department of Urology,Beijing Puren Hospital,Beijing 100062,China)

机构地区：[1]北京市普仁医院泌尿外科,北京100062

出　　处：《海军医学杂志》2025年第4期401-405,共5页Journal of Navy Medicine

摘　　要：目的分析前列腺液中的卵磷脂小体(SPL)、炎症因子及免疫球蛋白(Ig)与慢性前列腺炎(CP)的相关性。方法选取2022年1月至2023年12月北京市普仁医院泌尿外科收治的CP患者102例作为CP组,根据美国国立卫生研究院(NIH)CP病理分型将CP组的102例病例分为Ⅱ型组(n=32)、ⅢA型组(n=39)和ⅢB型组(n=31),根据病情严重程度将CP组的102例病例分为轻度组(n=33)、中度组(n=43)和重度组(n=26)。选取同期体检的健康男性34例作为对照组。比较各组前列腺液中的SPL、炎症因子及Ig水平,并分析上述指标与CP病理分型和病情严重程度的相关性。结果CP组SPL低于对照组(P<0.05),肿瘤坏死因子(TNF)⁃α、白细胞介素(IL)⁃6、IL⁃8、IgA、IgG、IgM高于对照组(P<0.05)。Ⅱ型组、ⅢA型组和ⅢB型组的SPL、IgA、IgG和IgM比较差异无统计意义(P>0.05);TNF⁃α、IL⁃6和IL⁃8比较差异有统计学意义(P<0.05),且Ⅱ型组>ⅢA型组>ⅢB型组。轻度组、中度组和重度组的SPL比较差异有统计学意义(P<0.05),且轻度组>中度组>重度组;TNF⁃α、IL⁃6、IL⁃8、IgA、IgG和IgM比较差异有统计学意义(P<0.05),且重度组>中度组>轻度组。Spearman相关性分析发现,SPL与病情严重程度呈负相关(P<0.05),TNF⁃α、IL⁃6和IL⁃8与病理分型和病情严重程度呈正相关,IgA、IgG和IgM与病情严重程度呈正相关(P<0.05)。结论前列腺液中的SPL、TNF⁃α、IL⁃6、IL⁃8、IgA、IgG和IgM与CP的病情严重程度相关,TNF⁃α、IL⁃6和IL⁃8与CP的病理分型相关。Objective To analyze the correlation between small patticle of lecithin,inflammatory factors,and immunoglobulins in prostatic fluid and chronic prostatitis(CP).Methods A total of 102 CP patients who were admitted to Beijing Puren Hospital from January 2022 to December 2023 were enrolled into CP group.According to the pathological classification of the National Institutes of Health in the United States,the patients were classified into typeⅡgroup(32 cases),typeⅢA group(39 cases),and typeⅢB group(31 cases).According to the severity of the disease,the patients were classified into mild group(33 cases),moderate group(43 cases),and severe group(26 cases).Meanwhile,34 healthy males who underwent physical examination were selected as controls.The levels of small patticle of lecithin(SPL),inflammatory factors,and immunoglobulins in prostate fluid were compared among groups.The relationship of these parameters with the pathological classification and severity of CP were analyzed.Results CP group had lower level of SPL and higher levels of tumor necrosis factor(TNF)⁃α,interleukin(IL)⁃6,IL⁃8,immunoglobulin(Ig)A,IgG,and IgM than control group(P<0.05).There was no significant difference in the SPL,IgA,IgG,or IgM among CP patients with different pathological types(P>0.05),but there were significant differences in the TNF⁃α,IL⁃6,and IL⁃8 levels(typeⅡgroup>typeⅢA group>typeⅢB group,P<0.05).There were significant differences in the SPL in CP patients with different severity levels(mild group>moderate group>severe group,P<0.05).So were the TNF⁃α,IL⁃6,IL⁃8,IgA,IgG,and IgM(severe group>moderate group>mild group,P<0.05).Spearman correlation analysis showed that SPL in the prostatic fluid was negatively correlated with the severity of CP(P<0.05);TNF⁃α,IL⁃6,and IL⁃8 were positively correlated with pathological classification and severity of CP(P<0.05);IgA,IgG,and IgM were positively correlated with the severity of CP(P<0.05).Conclusion SPL,TNF⁃α,IL⁃6,IL⁃8,IgA,IgG and IgM in prostatic fluid

关 键 词：慢性前列腺炎 前列腺液 卵磷脂小体 炎症因子 免疫球蛋白 

分 类 号：R697.33[医药卫生—泌尿科学]