基于同轴数字全息的呼出气溶胶粒子场诊断方法  

Diagnostic Method for Exhaled Aerosol Particle Field Based on Digital In-Line Holography

作　　者：赵德超 吕且妮[2] 王华英 甄迪 孙中伟 Zhao Dechao;LYU Qieni;Wang Huaying;Zhen Di;Sun Zhongwei(School of Mathematics and Physics,Hebei University of Engineering,Handan 056038,Hebei,China;School of Precision Instrument and Opto-Electronics Engineering,Tianjin University,Tianjin 300072,China;Hebei Computational Optical Imaging and Photoelectric Detection Technology Innovation Center,Handan 056038,Hebei,China;Hebei International Joint Research Center for Computational Optical Imaging and Intelligent Sensing,Handan 056038,Hebei,China)

机构地区：[1]河北工程大学数理科学与工程学院,河北邯郸056038 [2]天津大学精密仪器与光电子工程学院,天津300072 [3]河北省计算光学成像与光电检测技术创新中心,河北邯郸056038 [4]河北省计算光学成像与智能传感国际联合研究中心,河北邯郸056038

出　　处：《激光与光电子学进展》2025年第2期54-60,共7页Laser & Optoelectronics Progress

基　　金：国家自然科学基金(62175059)。

摘　　要：呼出气溶胶粒子场的粒子尺寸及其分布特性与健康状态有关,基于此,提出一种基于同轴数字全息的呼出气溶胶粒子场诊断方法。利用连通域方法,从呼出气溶胶粒子场数字全息图再现像中提取粒子尺寸,得到其粒径分布,计算统计参数(D10、D32、D43和DN50)。对14位健康和10位流感志愿者进行了测试,得到健康和流感志愿者的两组粒径统计参数分布及其平均值。在粒径统计参数分布区间内,计算检测正确率,得到每个统计参数的基准点。将这4个基准点和粒径统计参数平均值作为指标,对6位测试志愿者进行测试,根据准确率和变异系数(CV)最小的原则,选择索太尔平均直径作为健康状况判断准则,检测正确率高于80%。本研究为呼出气溶胶粒子场流感初步诊断提供了一种光学方法。The particle size and distribution characteristics of exhaled aerosol particle fields are related to the health status.This study proposes a diagnostic method for exhaled aerosol particle fields using coaxial digital holography.A connected domain method was employed to extract particle sizes from the reconstructed images of exhaled aerosol particle field holograms,determine particle size distributions,and calculate statistical parameters(D10,D32,D43,and DN50).The method was tested on 14 healthy volunteers and 10 infected patients to obtain the distribution and average values of two sets of particle size statistical parameters.The detection accuracy within the distribution range of particle size statistical parameters was calculated,and benchmark points for each statistical parameter were obtained.Using the four benchmark points and average particle size statistical parameters as indicators,six test volunteers were tested.By minimizing the accuracy and coefficient of variation,the Sauter mean diameter is identified as the optimal criterion for assessing the health status,achieving a detection accuracy rate of over 80%.This study introduces an optical method for the preliminary diagnosis of influenza through the analysis of exhaled aerosol particle fields.

关 键 词：数字全息 粒子场 气溶胶 感染诊断 流感 

分 类 号：O438.1[机械工程—光学工程]