动脉粥样硬化易损斑块分子影像探针研究:进展、挑战与展望  

Molecular imaging studies of atherosclerotic vulnerable plaques:progress,challenges and prospects

作　　者：张茜 叶豪奕[1,2] 崔思美 王威 高磊 ZHANG Xi;YE Hao-yi;CUI Si-mei;WANG Wei;GAO Lei(Senior Department of Cardiology,Sixth Medical Center of Chinese PLA General Hospital,Beijing 100853,China;Medical School of Chinese PLA,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院第六医学中心心血管病医学部,北京100853 [2]中国人民解放军医学院,北京100853

出　　处：《中国介入心脏病学杂志》2025年第4期215-221,共7页Chinese Journal of Interventional Cardiology

基　　金：北京市自然科学基金项目(7242138);中国人民解放军总医院第六医学中心创新培育基金项目(CXPY202202);首都卫生发展科研专项项目(首发2024-2-5072)。

摘　　要：动脉粥样硬化是心血管病的主要病理基础,其并发症如心肌梗死和脑卒中的主要诱因是动脉粥样硬化易损斑块(VASPs)的破裂。传统影像技术依赖解剖结构变化,难以在早期评估斑块易损性。近年来,分子影像结合纳米探针技术通过靶向斑块的病理特征(如脂质核心、炎症、薄纤维帽等),实现了细胞和分子水平的精准可视化。本文综述了VASPs的病理特征、现有影像技术的局限性,以及分子影像探针的设计原则与应用进展,探讨其临床转化面临的挑战与未来方向。Atherosclerosis(AS)is the major pathologic basis of cardiovascular disease,and its complications,such as myocardial infarction and stroke,are primarily triggered by rupture of atherosclerotic vulnerable plaques(VASPs).Conventional imaging techniques rely on anatomical changes,making it difficult to assess plaque vulnerability at an early stage.In recent years,molecular imaging combined with nanoprobe technology has enabled precise visualization at the cellular and molecular levels by targeting pathological features of plaques(e.g.,lipid core,inflammation,thin fibrous cap,etc.).This article reviews the pathological features of VASPs,the limitations of existing imaging techniques,and the design principles and application progress of molecular imaging probes and discusses the challenges and future directions for their clinical translation.

关 键 词：动脉粥样硬化 易损斑块 分子影像 

分 类 号：R543[医药卫生—心血管疾病]