Sodium dodecyl sulfate‐coated silver nanoparticles accelerate antimicrobial potentials by targeting amphiphilic membranes  

作　　者：Xiuyan Jin Na Peng Aoran Cui Yue Liu Xianqi Peng Linlin Huang Abdelaziz Ed‐Dra Fang He Yan Li Shikuan Yang Min Yue 

机构地区：[1]Department of Veterinary Medicine,Zhejiang University College of Animal Science,Hangzhou,China [2]School of Materials Science and Engineering,Institute for Composites Science Innovation,Zhejiang University,Hangzhou,China [3]Laboratory of Engineering and Applied Technologies,Higher School of Technology,M'ghila University Campus,Sultan Moulay Slimane University,Beni Mellal,Morocco [4]Laboratory of Animal Virology of Ministry of Agriculture,Zhejiang University,Hangzhou,China [5]Hainan Institute,Zhejiang University,Sanya,China [6]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,National Medical Center for Infectious Diseases,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China [7]Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,China

出　　处：《mLife》2024年第4期551-564,共14页微生物(英文)

基　　金：supported by the National Program on Key Research Project of China(2022YFC2604201);the European Union's Horizon 2020 Research and Innovation Programme(Grant Agreement No.861917-SAFFI);Zhejiang Provincial Key R&D Program of China(nos.2023C03045 and 2022C02024);Zhejiang Provincial Natural Science Foundation of China(LZ24C180002).

摘　　要：Compelling concerns about antimicrobial resistance and the emergence of multidrug‐resistant pathogens call for novel strategies to address these challenges.Nanoparticles show promising antimicrobial activities;however,their actions are hindered primarily by the bacterial hydrophilic–hydrophobic barrier.To overcome this,we developed a method of electrochemically anchoring sodium dodecyl sulfate(SDS)coatings onto silver nanoparticles(AgNPs),resulting in improved antimicrobial potency.We then investigated the antimicrobial mechanisms and developed therapeutic applications.We demonstrated SDS‐coated AgNPs with anomalous dispersive properties capable of dispersing in both polar and nonpolar solvents and,further,detected significantly higher bacteriostatic and bactericidal effects compared to silver ions(Ag^(+)).Cellular assays suggested multipotent disruptions targeting the bacterial membrane,evidenced by increasing lactate dehydrogenase,protein and sugar leakage,and consistent with results from the transcriptomic analysis.Notably,the amphiphilic characteristics of the AgNPs maintained robust antibacterial activities for a year at various temperatures,indicating long‐term efficacy as a potential disinfectant.In a murine model,the AgNPs showed considerable biocompatibility and could alleviate fatal Salmonella infections.Collectively,by gaining amphiphilic properties from SDS,we offer novel AgNPs against bacterial infections combined with long‐term and cost‐effective strategies.

关 键 词：amphiphilic properties antimicrobial agents antimicrobial resistance feed additive silver nanoparticles 

分 类 号：O62[理学—有机化学]