慢性踝不稳患者双侧下肢单脚站时脑激活的特征研究  

Cerebral cortical activity features of the individuals with chronic ankle instability during the bilateral sin⁃gle-leg balance task

作　　者：许枭云 马腾佳 薛啸傲 王逸然 陶唯楚 余乐 华英汇 XU Xiaoyun;MA Tengjia;XUE Xiao'ao(School of Exercise and Health,Shanghai University of Sport,Shanghai,200438;不详)

机构地区：[1]上海体育学院运动健康学院,上海市200438 [2]大连医科大学附属第二医院关节与运动医学科 [3]上海复旦大学附属华山医院运动医学科

出　　处：《中国康复医学杂志》2025年第4期550-554,共5页Chinese Journal of Rehabilitation Medicine

基　　金：国家自然科学基金项目(81871823)。

摘　　要：目的:采用功能性近红外光谱技术(functional near-infrared spectroscopy,fNIRS)探究慢性踝不稳人群、健康无扭伤人群双侧下肢在执行单脚站任务时的脑皮层激活特点。方法:纳入16例健康未扭伤受试者、16例单侧慢性踝不稳受试者,在左右单脚站的任务状态下,同时进行fNIRS脑功能信号采集。基于氧合血红蛋白(HbO2)的浓度变化,计算两组受试人群各脑区的激活程度(β值),并在背外侧前额叶区、初级感觉区、辅助运动区、颞中回等九个脑区层面比较双侧下肢在单脚站任务时的组间差异。结果:基于激活程度(β值)的皮层分析发现,慢性踝不稳人群进行患腿单脚站时,右侧辅助运动区(ch28)、左侧韦尼克区(ch51)显著激活;慢性踝不稳人群进行健腿单脚站时,右侧背外侧前额叶区(ch15)、初级感觉区(ch33)、颞中回(ch40)显著激活。结论:慢性踝不稳患者双侧下肢单脚站任务下脑皮层激活特征均与健康未扭伤人群有异,存在姿势控制神经机制的改变。姿势控制状态下,背外侧前额叶区、躯体感觉区、颞中回区、辅助运动区、韦尼克区激活高于健康组。Objective:To measure the cerebral cortical activity by the functional near-infrared spectroscopy,fNIRS during the bilateral single-leg standing in population with chronic ankle instability(CAI)and healthy controls.Method:Sixteen healthy participants without any sprains and 16 participants with unilateral CAI were recruited.The fNIRS was used to collect the brain function signals during the bilateral single-leg standing task.Based on the concentration of oxyhemoglobin(HbO2),the functional activation(βvalue)of each brain region of the two groups was calculated,and the differences between the groups during the tasks were compared in nine brain regions,including the dorsolateral prefrontal cortex(DLPFC),primary sensory area(S1),supplementary motor area(SMA),and middle temporal gyrus(MTG).Result:Compared to healthy participants,CAI participants exhibited significantly increased cortical activity based on theβvalue in right SMA(ch28)and left Wernicke's area(ch51)during the single-leg standing on the injured side.During the single-leg standing on the uninjured side,CAI participants exhibited significantly increased cortical activity in the right side of DLPFC(ch15),S1(ch33)and MTG(ch40).Conclusion:The cerebral cortex activation in patients with CAI is different from that in healthy people,according to the neural mechanism of posture control.There is a higher activation of DLPFC,S1,MTG,SMA,and Wernicke's area in CAI patients during the state of postural control.

关 键 词：慢性踝不稳 双侧 功能性近红外光谱技术 

分 类 号：R493[医药卫生—康复医学] R684[医药卫生—临床医学]