新型芳氧苯胺类化合物的合成及除草活性研究  

Synthesis and Herbicidal Activity of Novel Aryloxyaniline Analogues

作　　者：郝泽生 王滢秀 王海利 张晓慷 张新刚 江忠萍 韩金涛 HAO Zesheng;WANG Yingxiu;WANG Haili;ZHANG Xiaokang;ZHANG Xingang;JIANG Zhongping;HAN Jintao(Shandong Academy of Pesticide Sciences,Jinan 250100,China)

机构地区：[1]山东省农药科学研究院,山东济南250100

出　　处：《山东化工》2025年第6期1-3,8,共4页Shandong Chemical Industry

基　　金：山东省自然科学基金(ZR^(2)022QC224);山东省农业科学院农业科技创新工程(CXGC2024F18);山东省技术创新引导计划(中央引导地方科技发展资金)(YDZX2023051)。

摘　　要：以芳氧苯氧丙酸酯类除草剂-异噁草醚为先导,通过生物电子等排、骨架跃迁等方法,设计合成了一系列含有芳氧苯胺结构的化合物,对所合成的目标化合物进行了NMR表征,确定了目标化合物的结构,并进行了除草活性,测试结果表明,大部分化合物对稗草、狗尾草、苘麻和百日草均具有一定的除草活性。其中,化合物Ⅰ-4(4-((4-硝基吡啶-2-基)氧基、苯基)氨基甲酸4-氯-2甲基苯酯)表现出广谱的除草活性,500 g/hm^(2)含量下,对稗草和狗尾草的除草活性大于90%,对苘麻和百日草的除草活性大于40%,优于对照药剂异噁草醚,作为除草剂具有进一步研究的潜力。With aryloxyphenoxypropionate herbicide clomazone as the lead compound,a series of compounds containing aryloxy aniline structures were designed and synthesized by bioisosterism and scaffold hopping method.The NMR characterization was carried out to determine the structures of the target compounds,and their herbicidal activities were tested.The test results indicated that that most of the compo unds had certain herbicidal activity against Echinochloa crusgalli,Setaria viridis,Abutilon theophrasti and Zinnia elegans.Among them,compound I-4 showed broad-spectrum herbicidal activity.At a concentration of 500 g/hm^(2),compound I-4 exhibited more than 90%herbicidal activity against Echinochloa crusgalli,Setaria viridis,which was comparable to acetochlor;more than 40%herbicidal activity against Abutilon theophrasti and Zinnia elegans,which was significantly better than that of acetochlor,and it has the potential for further research as a herbicide.

关 键 词：芳氧苯胺 合成 除草活性 构效关系 

分 类 号：TQ457[化学工程—农药化工]