双功能半导体聚合物纳米颗粒复合载药系统的构建  

Construction of a Bifunctional Semiconductor Polymer Nanoparticle-Based Drug Delivery System

作　　者：邢煜骞 赵曼 XING Yuqian;ZHAO Man(Jinhua University of Vocational Technology,Jinhua 321000,China)

机构地区：[1]金华职业技术大学,浙江金华321000

出　　处：《山东化工》2025年第6期12-15,共4页Shandong Chemical Industry

基　　金：浙江省金华市公益类科学技术研究计划项目(2021-4-109)。

摘　　要：开发了一种基于温敏聚合物修饰的半导体聚合物纳米颗粒(SPNs)的纳米复合载药系统,可用于增强癌症的联合治疗效果。该系统以SPNs为核心,外层为温敏聚合物,通过吸收近红外激光能量实现光热转换。升温后不仅可直接烧蚀肿瘤细胞,同时触发温敏聚合物构象变化,从而释放嵌入的抗肿瘤药物阿霉素。实验结果显示,该纳米复合物具有优异的药物负载效率(90.2%)和光热转换性能(50μg/mL,10 min升温25℃)。此外,近红外激光照射可以使该系统的光控药物释放性能在6 h达到53.6%。该纳米复合载药平台在肿瘤联合治疗领域具有显著的潜在应用价值。This study developed a nanocomposite drug delivery system based on thermosensitive polymer-modified semiconductor polymer nanoparticles(SPNs)for enhancing the efficacy of combined cancer therapy.The system centers on SPNs with an outer thermosensitive polymer layer,enabling photothermal conversion upon near-infrared(NIR)laser irradiation.The temperature increase not only directly ablates tumor cells but also induces conformational changes in the thermosensitive polymer,thereby releasing the embedded anticancer drug Doxorubicin.Experimental results demonstrate that this nanocomposite possesses excellent drug loading efficiency(90.2%)and photothermal conversion efficiency(raising temperature by 25℃at 50μg/mL in 10 min).Additionally,NIR laser irradiation facilitates controlled drug release,reaching 53.6%over 6 h.This nanocomposite drug delivery platform shows significant potential for application in the field of tumor combination therapy.

关 键 词：半导体聚合物纳米颗粒 光热效应 药物控制释放 温敏聚合物 联合治疗 

分 类 号：TQ460[化学工程—制药化工]