五元、六元以及七元苯并磺内酰胺化合物的研究进展  

Recent Syntheses of Five-,Six-and Seven-membered Benzosultams

作　　者：刘爱云 王刚 王志学 LIU Aiyun;WANG Gang;WANG Zhixue(School of Applied Chemical Engineering,Lanzhou Petrochemical University of Vocational Technology,Lanzhou 730060,China)

机构地区：[1]兰州石化职业技术大学应用化学工程学院,甘肃兰州730060

出　　处：《山东化工》2025年第6期75-79,共5页Shandong Chemical Industry

基　　金：甘肃省教育厅创新基金项目(2022A-210);2024年高校教师创新基金项目(2024A-237)。

摘　　要：五元、六元以及七元苯磺内酰胺化合物在医药、农药、有机合成等诸多领域有着非常重要的意义和应用价值,本文总结了(2008~2022年)五元、六元以及七元苯并磺内酰胺化合物合成的方法,包括分子内过渡金属催化或化学计量高价碘介导的C-H胺化;分子内过渡金属催化的交叉偶联;芳基磺酰胺与炔烃、烯烃或其他双碳合成子的分子间环化反应以及其他的一些方法,我们希望该综述将对该领域的科研人员提供一些思路。Five-,Six-,Seven-membered benzosultams are an important class of nitrogen-containing heterocycles that possess a wide range of biological and pharmacological activities,including antimicrobial,antitumor and antiviral effects.This review summarizes the synthetic methods of Five-,Six-,Seven-membered benzosultams from 2008 to 2022,mainly including intramolecular transition-metal(TM)-catalyzed or stoichiometric hypervalent iodine-mediated C-H amination,intramolecular TM-catalyzed cross-coupling,intermolecular annulation reactions of aryl sulfonamides with alkynes,alkenes or other two-carbon synthons,as well as some other methods.In this review,these synthetic methods are summarized,in order to provide a reference for the design and research of these compounds.

关 键 词：五元苯磺内酰胺 六元苯磺内酰胺 七元苯磺内酰胺 

分 类 号：O626.3[理学—有机化学]