基于中西医临床病证特点的卵巢储备功能减退动物模型分析  

Evaluation of Animal Models with Diminished Ovarian Reserve Based on Clinical Disease and Syndrome Characteristics of Traditional Chinese Medicine and Western Medicine

作　　者：于明玥 汤玲[1] 孙晓卉 赵静静 YU Mingyue;TANG Ling;SUN Xiaohui;ZHAO Jingjing(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院,北京100700

出　　处：《中国实验方剂学杂志》2025年第9期240-248,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：首都卫生发展科研专项(首发2024-2-4196);北京中医药薪火传承“新3+3”工程室站建设项目(JX572)。

摘　　要：目的:随着社会的发展及女性对高龄妊娠需求的增加,卵巢储备功能减退(DOR)受到愈加广泛的关注。该疾病不仅影响女性的正常月经,更对女性的心理健康带来威胁。目前对于DOR的研究尚处于初步探索阶段,构建有效且吻合实际的动物模型是推进DOR研究进展的刚需。该研究欲利用现有文献资料结合DOR的中西医诊断标准,对已有模型进行归纳、分析和评价,为优化DOR动物模型提供参考。方法:对DOR相关动物模型文献进行回顾性分析,梳理DOR中西医诊断标准,根据动物模型评价方法,评价各模型中西医临床吻合度。结果:DOR动物模型包括自然因素模型、医源因素模型、免疫因素模型、代谢因素模型及环境因素模型。其中,医源因素模型尤其是雷公藤制剂、环磷酰胺及顺铂诱导的动物模型无论在西医疾病方面还是中医证型方面均有较高的吻合度,是目前研究DOR的最优造模方法。结论:现有的DOR造模方法大多具有较高的西医疾病临床吻合度,而具有明确中医证型的DOR动物模型数量甚少。在探索DOR治疗方案之路上,中医药的作用不可忽视,因而应更加积极地研发中医证型相关性DOR动物模型,更好地挖掘中医药的潜能,为促进应用中医药治疗DOR提供有力的理论支撑。Objective:With the development of society and the increasing demand for pregnancy at an advanced age,diminished ovarian reserve(DOR)has attracted wider attention.This disease affects the normal menstruation of women and poses a threat to their mental health.Current research on DOR is still in the initial stage,and advancing research progress in DOR necessitates the construction of effective and clinically relevant animal models.Building on existing literature and integrating the diagnosis criteria of DOR in traditional Chinese medicine(TCM)and Western medicine,this study summarized,analyzed,and evaluated existing models,providing a reference for optimizing DOR animal models.Methods:A retrospective analysis of literature on DOR-related animal models was conducted,and the diagnostic criteria of DOR in TCM and Western medicine were sorted out.By means of evaluation methods of animal models,the clinical relevance of each model to TCM and Western medicine was assessed.Results:DOR animal models included those based on natural factors,iatrogenic factors,immune factors,metabolic factors,and environmental factors.Among them,the model based on iatrogenic factors,especially models induced by Tripterygium wilfordii preparations,cyclophosphamide,and cisplatin,had a high degree of relevance to both Western medical diseases and TCM syndromes and was confirmed as the optimal modeling method for studying DOR at present.Conclusion:The existing DOR modeling methods mostly have a high degree of clinical relevance to Western medical diseases,while the number of DOR animal models with clear TCM syndromes is very limited.TCM plays an indispensable role in exploring DOR treatment methods.Therefore,the development of DOR animal models related to TCM syndromes should be strengthened,further exploring the potential of TCM and providing strong theoretical support for the application of TCM in DOR treatment.

关 键 词：卵巢储备功能减退 动物模型 病证结合 

分 类 号：R711[医药卫生—妇产科学] R285[医药卫生—临床医学] R289