中医药调控JAK/STAT信号通路干预肺癌的机制研究进展  

Mechanism of Traditional Chinese Medicine Regulating JAK/STAT Signaling Pathway to Intervene in Lung Cancer:A Review

作　　者：曹家瑞 冯博 马纯政 陈伟霞 喻江凡 曹莎莎 张振予 欧阳文慧 CAO Jiarui;FENG Bo;MA Chunzheng;CHEN Weixia;YU Jiangfan;CAO Shasha;ZHANG Zhenyu;OUYANG Wenhui(The Second Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan Province Hospital of Traditional Chinese Medicine/The Second Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450002,China)

机构地区：[1]河南中医药大学第二临床医学院,郑州450046 [2]河南省中医院/河南中医药大学第二附属医院,郑州450002

出　　处：《中国实验方剂学杂志》2025年第9期265-276,共12页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：第二批国家中医临床研究基地(国中医药科技函〔2018〕131号);河南省重点研发与推广专项(科技攻关)项目(232102310126);河南省中医药科学研究专项(2022ZY2031)。

摘　　要：肺癌是全球癌症发病率与死亡率均居首位的恶性肿瘤,目前针对肺癌的治疗手段主要有手术、化疗、靶向治疗、免疫治疗,但其不良反应、耐药性和带来的经济压力仍是其主要的局限性。Janus激酶(JAK)/信号转导与转录激活因子(STAT)信号通路作为重要的癌症通路之一,可通过调节其下游多种靶点,从多种途径调节肿瘤的发生发展,因此JAK/STAT信号通路为肺癌的治疗提供新的研究方向。多项研究表明,JAK/STAT信号通路在肺癌细胞的增殖生长、血管的生成、上皮-间质转化(EMT)、代谢的改变、免疫微环境的重塑、治疗耐药性的产生中发挥着重要作用。中医药因其不良反应小、经济负担小及与西医治疗合用可起到增效减毒的作用而愈加受到重视。除了传统的中药复方,更多的中药单体因其具有更精准的效果也逐渐走进大众视野。诸多关于中医药调控JAK/STAT信号通路治疗肺癌的研究发现中医药可通过干预JAK/STAT信号通路,抑制肺癌细胞的增殖与侵袭、肿瘤异常血管的生成、EMT及改善炎症微环境和免疫抑制微环境、增加对治疗的敏感性,从而阻碍肺癌的发展。近年来中药调控此通路治疗肺癌的研究更新迅速,而对这些研究的总结却未能及时更新,故该文将从介绍JAK/STAT通路、阐述此通路在肺癌中的作用机制、探索中医药通过此通路干预肺癌治疗这3个方面,对近年中药调控JAK/STAT信号通路干预肺癌的研究成果进行补充总结与反思,以期为今后肺癌的治疗提供更多参考。Lung cancer is the malignant tumor with the highest incidence and mortality rates globally.Current treatment methods for lung cancer primarily include surgery,chemotherapy,targeted therapy,and immunotherapy.However,the main limitations of these treatments are their side effects,the drug resistance,and the economic burden they impose.As a critical cancer pathway,the Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling pathway regulates tumor occurrence and development through multiple mechanisms by influencing various downstream targets.Consequently,the JAK/STAT signaling pathway offers a promising avenue for lung cancer treatment research.Numerous studies have demonstrated that the JAK/STAT signaling pathway plays a key role in the proliferation and growth of lung cancer cells,angiogenesis,epithelialmesenchymal transition(EMT),metabolic alterations,remodeling of the immune microenvironment,and the development of treatment resistance.Traditional Chinese medicine(TCM)has garnered increasing attention due to its minimal side effects,low economic burden,and its potential to enhance efficacy and reduce toxicity when used in conjunction with Western medicine.In addition to traditional Chinese medicine compounds,a growing number of Chinese medicine monomers have come into the spotlight because of their more targeted effects.Numerous studies investigating the regulation of the JAK/STAT signaling pathway by TCM in the treatment of lung cancer have demonstrated that TCM can inhibit the proliferation and invasion of lung cancer cells,tumor angiogenesis,and EMT,improve the inflammatory and immunosuppressive microenvironments,and enhance treatment sensitivity by intervening in the JAK/STAT signaling pathway,thereby impeding the progression of lung cancer.In recent years,the research on the regulation of this pathway by TCM in the treatment of lung cancer has been updated rapidly.However,the summary of these studies has not been updated in time.This review summarizes and reflects on the recent rese

关 键 词：Janus激酶(JAK)/信号转导与转录激活因子(STAT) 中药单体 中药复方 肺癌 A549细胞 细胞周期 免疫 

分 类 号：R256[医药卫生—中医内科学] R285.5[医药卫生—中医学] R734.2