VEGF信号通路在结直肠癌病理机制中的作用及中医药干预研究现状  

Role of VEGF Signaling Pathway in Pathological Mechanism of Colorectal Cancer and Traditional Chinese Medicine Intervention:A Review

作　　者：刘秋宁 祝雨田 许云[3] 叶阳 贾小强[3] LIU Qiuning;ZHU Yutian;XU Yun;YE Yang;JIA Xiaoqiang(Beijing University of Chinese Medicine,Beijing 100029,China;Peking University Third Hospital,Beijing 100191,China;Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京大学第三医院,北京100191 [3]中国中医科学院西苑医院,北京100091

出　　处：《中国实验方剂学杂志》2025年第9期289-296,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(8207142801);中国中医科学院西苑医院提升中医药临床循证证据级别研究项目(XYZX020107);中国中医科学院科技创新工程项目(CI2021A0091)。

摘　　要：结直肠癌是一种起源于结肠与直肠上皮细胞的恶性肿瘤,是世界上发病率第三高与死亡率第二高的恶性肿瘤。随着我国经济水平的快速发展与饮食习惯的日益西化,其在我国的发病率也在逐年增加。在过去的十几年间,尽管有大量关于结直肠癌的治疗方法问世,但现有相关治疗方法的疗效仍不尽如人意。近年来,中医凭借其多靶点、多途径及低不良反应的优势在结直肠癌的治疗中成为一大焦点。血管内皮生长因子(VEGF)是一种重要的血管生成因子,其可通过促进血管生成为肿瘤的生长提供营养及氧气,并增加血管的通透性而使肿瘤细胞易于穿过血管壁进入其他组织,进而发生转移。多项研究表明,中医药可通过作用于VEGF信号通路,进而发挥抑制肿瘤血管与淋巴管生成、促进肿瘤细胞凋亡及抑制结直肠癌细胞增殖的作用,从而延缓肿瘤的生长。过去几年该领域的文章更新迅速,但却缺少相关的整理,这给后续的文献检索提供了不便,故该文从VEGF信号通路的生理功能、VEGF信号通路在结直肠癌发生中的作用及中医药对VEGF的干预三方面入手,对相关信息进行补充与总结,以期为后续相关研究提供参考。Colorectal cancer is a malignant tumor that originates from the epithelial cells of the colon and rectum.It has the third highest incidence and the second highest mortality rate among malignant tumors worldwide.With the rapid development of the economy and the increasing Westernization of dietary habits in China,its incidence in China has been rising year by year.Over the past decade,despite the introduction of numerous treatment methods for colorectal cancer,the efficacy of existing therapies remains unsatisfactory.In recent years,traditional Chinese medicine(TCM)has become a major focus in the treatment of colorectal cancer due to its advantages of multi-target,multi-pathway mechanisms and low toxicity and side effects.Vascular endothelial growth factor(VEGF)is an important angiogenic factor that promotes blood vessel formation,providing nutrients and oxygen for tumor growth.It also increases vascular permeability,allowing tumor cells to easily pass through the blood vessel wall into other tissues,thereby facilitating metastasis.Several studies have shown that TCM can inhibit tumor angiogenesis and lymphangiogenesis,promote tumor cell apoptosis,and inhibit the proliferation of colorectal cancer cells by acting on the VEGF signaling pathway,thereby delaying tumor growth.In recent years,research in this field has been rapidly updated,but there is a lack of relevant summaries,making subsequent literature searches inconvenient.Therefore,this article focuses on the physiological functions of the VEGF signaling pathway,its role in the occurrence of colorectal cancer,and the intervention of TCM on VEGF,providing a supplement and summary of relevant information to offer a reference for future research in this area.

关 键 词：血管内皮生长因子(VEGF) 信号通路 结直肠肿瘤 分子机制 中医药 

分 类 号：R273[医药卫生—中西医结合] R242[医药卫生—中医肿瘤科] R574[医药卫生—中医学]