清瘟败毒饮及其活性成分防治肺损伤的研究进展  

Research Progress on Qingwen Baidu Decoction and Its Active Ingredients in Prevention of Lung Injury

作　　者：林晓洁 温夏楠 曾巧琳 王丽 郑远茹 赵杰 LIN Xiaojie;WEN Xianan;ZENG Qiaolin;WANG Li;ZHENG Yuanru;ZHAO Jie(School of Health Science,Guangdong Pharmaceutical University,Guangzhou 510006,China;College of Pharmacy,Guangzhou Health Science College,Guangzhou 510450,China;School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China)

机构地区：[1]广东药科大学健康学院,广州510006 [2]广州卫生职业技术学院药学院,广州510450 [3]广东药科大学药学院,广州510006

出　　处：《中国实验方剂学杂志》2025年第9期315-322,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广州市教育局高校科研项目(2024312486);广东省普通高校特色创新类项目(2024KTSCX295);广州市基础与应用基础研究项目(2024A04J4897);广东省中医药局科研项目(20251217,20251210)。

摘　　要：急性肺损伤(ALI)是以急性进行性呼吸衰竭为特征的一种常见且死亡率高的临床综合征。目前,ALI的治疗以呼吸支持治疗和对症药物治疗为主,仍缺乏特异而有效的药物治疗。清瘟败毒饮是一种传统的中药方剂,具有清热解毒、凉血泻火的功效,其药理作用包括抗炎、解热、抗菌、抗病毒、镇静等方面。该方含有的黄酮类、酚类、萜类等成分具有较强的药理活性,可以调节ALI中的炎症反应和氧化应激,通过抗细胞凋亡,抗病原体感染和抗肺纤维化等途径维持肺泡-毛细血管屏障(ACB)的完整性,从而改善肺组织病理变化,其中黄酮类成分研究报道较多,作用机制复杂多样,如槲皮素、木犀草素、黄芩苷等,可作用于信号传导转录激活因子3(STAT3)、丝裂原活化蛋白激酶3(MAPK3)等多个重要靶点,通过调节Toll样受体4(TLR4)/髓样分化因子88(MyD88)/核转录因子-κB(NF-κB)、核因子E_(2)相关因子2(Nrf2)/Kelch样ECH相关蛋白1(Keap1)和沉默信息调节因子1(SIRT1)/转录因子叉头框蛋白O1(FoxO1)等信号通路,进而干预炎症反应、氧化应激、细胞凋亡和纤维化等病理事件。该文旨在综述清瘟败毒饮及其活性成分在防治肺损伤方面的研究进展,以期为后续清瘟败毒饮的药理机制研究提供参考,为其在ALI治疗中的临床应用及药物研发提供理论支撑。Acute lung injury(ALI)is a common and highly lethal clinical syndrome characterized by acute progressive respiratory failure.Currently,the treatment of ALI primarily involves respiratory support therapy and symptomatic pharmacotherapy,yet there is still a lack of specific and effective pharmacological treatments.Qingwen Baidu decoction is a traditional Chinese medicine formula that has the effects of clearing heat,removing toxin,cooling blood,and purging fire.Its pharmacological effects include anti-inflammatory,antipyretic,antibacterial,antiviral,sedative,and so on.The flavonoids,phenols,terpenes,and other components contained in this formula have strong pharmacological activity,which can regulate the inflammatory response caused and oxidative stress in ALI and maintain the integrity of alveolar-capillary barrier(ACB)by antiapoptosis,anti-pathogen infection,and anti-pulmonary fibrosis,thereby improving the pathological changes of lung tissue.Among them,flavonoids have been reported more,and their mechanism of action is complex and diverse.For example,quercetin,luteolin,and baicalin act on multiple important targets,such as signal transducer and activator of transcription 3(STAT3),mitogen-activated protein kinase 3(MAPK3),etc.and participate in the regulation of Toll-like receptor 4(TLR4)/myeloid differentiation primary response 88(MyD88)/nuclear factor kappa B(NF-κB),nuclear factor erythroid 2-related factor 2(Nrf2)/Kelch-like ECH-associated protein 1(Keap1),and silent information regulator 1(SIRT1)/forkhead box protein O1(FoxO1)signaling pathways,thereby intervening in pathological events such as inflammation,oxidative stress,cell apoptosis,and fibrosis.This paper aims to review the research progress on Qingwen Baidu decoction and its active ingredients in the prevention and treatment of lung injury in the expectation of providing reference for its subsequent pharmacological mechanism research and theoretical support for its clinical application and drug development in the treatment of ALI.

关 键 词：清瘟败毒饮 肺损伤 急性肺损伤 活性成分 作用机制 

分 类 号：R284[医药卫生—中药学] R256[医药卫生—中医学] R289