2024年内蒙古自治区饮水型地方性氟中毒病区成人氟斑牙的影响因素分析  

Analysis of influencing factors of adult dental fluorosis in drinking water-borne endemic fluorosis areas of Inner Mongolia Autonomous Region in 2024

作　　者：赵凡 杨钟[2] 许凯峰 李粉霞[2] 张世芳 李昕晔 刘聪 李梦昕 郭玉晨 庄添瑞 李科 杨志羡 邓丹宇 张忠兵 郭志伟 Zhao Fan;Yang Zhong;Xu Kaifeng;Li Fenxia;Zhang Shifang;Li Xinye;Liu Cong;Li Mengxin;Guo Yuchen;Zhuang Tianrui;Li Ke;Yang Zhixian;Deng Danyu;Zhang Zhongbing;Guo Zhiwei(School of Public Health,Inner Mongolia Medical University,Hohhot 010110,China;Institute of Endemic Disease Control,Hohhot City Center for Disease Control and Prevention,Hohhot 010020,China;Department of Endemic Diseases,Helinger County Center for Disease Control and Prevention,Hohhot 011599,China;School of Public Health,Baotou Medical College,Baotou 014040,China;Laboratory of Endemic Diseases,Inner Mongolia Autonomous Regional Center for Disease Control and Prevention(Inner Mongolia Autonomous Regional Academy of Preventive Medicine),Hohhot 010080,China;Scientific Research and Education Department,Inner Mongolia Autonomous Regional Center for Disease Control and Prevention(Inner Mongolia Autonomous Regional Academy of Preventive Medicine),Hohhot 010080,China)

机构地区：[1]内蒙古医科大学公共卫生学院,呼和浩特010110 [2]呼和浩特市疾病预防控制中心地方病防制所,呼和浩特010020 [3]呼和浩特市和林格尔县疾病预防控制中心地方病科,呼和浩特011599 [4]包头医学院公共卫生学院,包头014040 [5]内蒙古自治区疾病预防控制中心(内蒙古自治区预防医学科学院)地方病实验室,呼和浩特010080 [6]内蒙古自治区疾病预防控制中心(内蒙古自治区预防医学科学院)科研与宣教处,呼和浩特010080

出　　处：《中华地方病学杂志》2025年第3期232-236,共5页Chinese Journal of Endemiology

基　　金：内蒙古自治区科技计划项目(2021GG0383)。

摘　　要：目的探讨内蒙古自治区饮水型地方性氟中毒病区成人氟斑牙的影响因素。方法采用病例-对照研究方法,于2024年1月选取内蒙古自治区呼和浩特市和林格尔县饮水型地方性氟中毒病区的成人氟斑牙人群(病例组)与健康人群(对照组)作为调查对象,采集尿样检测尿氟浓度,并对其进行问卷调查。采用SPSS 25.0软件进行χ^(2)检验和多因素logistic回归分析。应用限制性立方样条(RCS)分析尿氟浓度与成人氟斑牙患病风险之间的关联。结果共纳入调查对象161人,其中病例组100人、对照组61人。单因素分析结果显示,病例组与对照组的性别、吸烟和尿氟浓度分布情况比较,差异均有统计学意义(χ^(2)=7.54、5.02、9.69,均P<0.05)。多因素logistic回归分析结果显示,性别(OR=0.36,95%CI:0.18~0.73,P=0.005)、尿氟浓度(OR=3.08,95%CI:1.46~6.67,P=0.003)是饮水型地方性氟中毒病区成人氟斑牙的影响因素。RCS分析显示,氟斑牙患病风险与尿氟浓度呈显著的线性剂量-效应关系(P总趋势=0.001,P非线性=0.071)。当尿氟浓度>1.57 mg/L时,随着尿氟浓度的升高,氟斑牙患病风险也随之增加。结论性别和尿氟浓度是内蒙古自治区饮水型地方性氟中毒病区成人氟斑牙的影响因素。Objective To investigate the influencing factors of adult dental fluorosis in drinking water-borne endemic fluorosis areas of Inner Mongolia Autonomous Region.Methods A case-control study was conducted in January 2024 to select adult fluorosis patients(case group)and healthy individuals(control group)from the drinking water-borne endemic fluorosis areas in Helinger County,Hohhot City,Inner Mongolia Autonomous Region as the survey subjects.Urine samples were collected to determine urinary fluoride concentration.A questionnaire survey was conducted.SPSS 25.0 software was used for χ^(2) test and multivariate logistic regression analysis.Restricted cubic spline(RCS)was used to analyze the association between urinary fluoride concentration and the risk of dental fluorosis in adults.Results A total of 161 individuals were included in the survey,including 100 in the case group and 61 in the control group.The results of univariate analysis showed that there were statistically significant differences in the distribution of gender,smoking,and urinary fluoride concentration between the case group and the control group(χ^(2)=7.54,5.02,9.69,P<0.05).The results of multivariate logistic regression analysis indicated that gender(OR=0.36,95%CI:0.18-0.73,P=0.005)and urinary fluoride concentration(OR=3.08,95%CI:1.46-6.67,P=0.003)were the influencing factors of adult fluorosis.RCS analysis showed a significant linear dose-response relationship between the risk of dental fluorosis and urinary fluoride concentration(P overall trend=0.001,P nonlinear=0.071).When the urinary fluoride concentration was greater than 1.57 mg/L,the risk of dental fluorosis increased with the increase of urinary fluoride concentration.Conclusion Gender and urinary fluoride concentration are the risk factors of dental fluorosis in adults in drinking water-borne endemic fluorosis areas of Inner Mongolia Autonomous Region.

关 键 词：成人 氟斑牙 饮水型地方性氟中毒 影响因素 

分 类 号：R599.9[医药卫生—内科学]