TIMP1和IL-1β在增生性瘢痕中的表达水平及相关性分析  

Expression levels and correlation analysis of TIMP1 and IL⁃1βin hypertrophic scars

作　　者：王俊歌 黄悦 陶凯 张园程 周大鹏 WANG Jun-ge;HUANG Yue;TAO Kai;ZHANG Yuan-cheng;ZHOU Da-peng(Department of Burn and Plastic Surgery,Northern Theater Command General Hospital,Shenyang 110016,China)

机构地区：[1]北部战区总医院烧伤整形科,辽宁沈阳110016

出　　处：《解剖科学进展》2025年第1期96-98,共3页Progress of Anatomical Sciences

基　　金：辽宁省民生科技计划联合计划(2021JH2/10300108)。

摘　　要：目的 探讨TIMP1和IL-1β在增生性瘢痕组织中的表达情况及相关性。方法 选取6例正常瘢痕和6例增生性瘢痕组织,HE染色观察瘢痕组织病理学改变,免疫组织化学染色检测TIMP1在组织中的表达情况,Western blot和ELISA方法检测TIMP1和IL-1β在组织中的表达情况,通过皮尔逊相关系数分析TIMP1和IL-1β在组织中的相关性。结果 增生性瘢痕组织中的胶原纤维密度增高,且排列紊乱,并且成纤维细胞和炎症细胞显著上调;TIMP1和IL-1β在增生性瘢痕组织中表达显著高于正常组织,且二者表达呈正相关。结论 TIMP1和IL-1β在增生性瘢痕组织中表达上调,并且二者表达呈正相关。Objective To investigate the expression and correlation of TIMP1 and IL⁃1βin hypertrophic scar tissues.Methods Six cases of normal scar tissue and six cases of hypertrophic scar tissue were selected.The histopathological changes of scars were observed by HE staining.The expression of TIMP1 in tissues was deteceted by immunohistochemical staining.The expression of TIMP1 and IL⁃1βin tissues were deteceted by Western blot and ELISA.The correlation between TIMP1 and IL⁃1βin tissues was analyzed by pearson correlation coefficient.Result The density of collagen fibers in hypertrophic scar tissue was increased,and the arrangement of collagen fibers was disordered,and fibroblasts and inflammatory cells were significantly upregulated.The expressions of TIMP1 and IL⁃1βin hypertrophic scar tissue was significantly higher than that in normal tissue,and their expressions were positively correlated.Conclusion The expression of TIMP1 and IL⁃1βwas up⁃regulated in hypertrophic scar tissue,and their expressions were positively correlated.

关 键 词：组织金属蛋白酶抑制因子1 白细胞介素1Β 增生性瘢痕 

分 类 号：R644[医药卫生—外科学]